Birth weight of infants of mothers with aggressive periodontitis.
Birth weight of infants of mothers with aggressive periodontitis.
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DOI：
10.1902/jop.2011.110192
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发表时间：
2012-03
影响因子：
4.3
通讯作者：
Gunsolley JC
中科院分区：
文献类型：
--
作者：
Schenkein HA;Koertge TE;Sabatini R;Brooks CN;Gunsolley JC
据推测，如果牙周感染易导致低出生体重和早产，那么当母亲患有侵袭性牙周炎（AgP）时，这种结果应该是明显的。出生体重数据收集问卷调查的女性与牙周健康的兄弟姐妹，和无关的牙周健康的妇女。采用前瞻性和回顾性出生结局数据。由于许多牙周评估是在出生后进行的，因此关于低出生体重的大多数风险因素的数据不完整。我们确定了母亲的牙周诊断和临床变量和报告的出生体重之间的关联。对照组和AgP组婴儿的平均出生体重无显著差异。无论是考虑所有出生还是仅考虑牙周检查前<1或2年报告的出生，这都是正确的。对于牙周健康的对照组，AgP患者的兄弟姐妹所生的婴儿中有13.2%和无血缘关系的母亲所生的婴儿中有12.8%体重<2，500 g，而泛发性AgP母亲所生的婴儿中有9.9%体重<2，500 g，而局限性AgP母亲所生的婴儿中有10.3%体重<2，500 g。由于AgP在人群中相对罕见，并且在进行其与妊娠结局相关性的前瞻性研究时存在困难，我们使用了一种折衷的方法，使用前瞻性数据以及较弱的回顾性数据，假设疾病可能在出生前发作。我们的研究结果，在这种方法的局限性，表明没有证据表明，在母亲的AgP易患低出生体重。AgP具有许多独特的生物学特征，将其与慢性牙周病区分开来，并且可能缺乏与出生体重的相关性可能是另一个这样的特征。
It was hypothesized that if periodontal infections predispose low birth weights and premature birth, then such outcomes should be apparent when the mother has aggressive periodontitis (AgP). Birth weight data were collected by questionnaire from females with AgP, their periodontally healthy siblings, and unrelated periodontally healthy women. Both prospective and retrospective birth outcome data were used. Because many of the periodontal evaluations were performed after the births, there were incomplete data regarding most of the risk factors for low birth weight. We determined associations between mothers’ periodontal diagnoses and clinical variables and the reported birth weights. There were no significant differences in mean birth weights of babies born to control subjects or AgP patients. This was true whether all the births were considered or only those reported <1 or 2 years before periodontal examination. For periodontally healthy controls, 13.2% of babies born to siblings of AgP patients and 12.8% of babies born to unrelated mothers weighed <2,500 g, whereas 9.9% of those born to mothers with generalized AgP and 10.3% of those born to mothers with localized AgP weighed <2,500 g. Because of the relative rarity of AgP in the population, and attendant difficulties in performing a prospective study of its association with pregnancy outcomes, we used a compromised approach using prospective data as well as weaker retrospective data assuming that disease onset was likely before the births. Our results, within the limitations of this approach, indicate no evidence that AgP in the mother predisposes low birth weights. AgP has many unique biologic characteristics that differentiate it from chronic forms of periodontal disease, and the possible lack of its association with birth weight may be another such characteristic.
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影响因子：
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