Maternal footprints of Southeast Asians in North India.
Maternal footprints of Southeast Asians in North India.
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DOI：
10.1159/000114160
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发表时间：
2008
期刊：
影响因子：
1.8
通讯作者：
Singh, Lalji
中科院分区：
文献类型：
--
作者：
Thangaraj, Kumarasamy;Chaubey, Gyaneshwer;Kivisild, Toomas;Rani, Deepa Selvi;Singh, Vijay Kumar;Ismail, Thanseem;Carvalho-Silva, Denise;Metspalu, Mait;Bhaskar, L. V. K. S.;Reddy, Alla G.;Chandra, Sarat;Pande, Veena;Naidu, B. Prathap;Adarsh, Niharika;Verma, Abhilasha;Jyothi, Inaganti Amara;Mallick, Chandana Basu;Shrivastava, Nidhi;Devasena, Ragala;Kumari, Babita;Singh, Amit Kumar;Dwivedi, Shailendra Kumar Dhar;Singh, Shefali;Rao, Geeta;Gupta, Pranav;Sonvane, Vartika;Kumari, Kavita;Basha, Afsar;Bhargavi, K. R.;Lalremruata, Albert;Gupta, Arvind Kumar;Kaur, Gurukamal;Reddy, K. K.;Rao, A. Papa;Villems, Richard;Tyler-Smith, Chris;Singh, Lalji
我们分析了来自印度125个不同种姓、部落和宗教群体的7137个样本和来自尼泊尔三个人群的99个样本，以了解线粒体DNA COII/tRNALys区域的长度变异。对显示长度变异的样品进行基于HVS-I和信息编码区序列变异的详细系统发育分析。在南亚，9-bp缺失和插入变体的总体频率分别为1.8%和0.5%。我们还定义了一个新的深根单倍群M43，并确定了罕见的单倍群H14在印度人口携带9 bp缺失的完整的mtDNA测序。此外，我们重新定义了单倍群M6，并将其分解为两个定义明确的亚支。北方邦的单倍群F1和B5 a的存在表明，从东南亚到北方印度的母系贡献较小。在尼泊尔样本中出现单倍群F1意味着尼泊尔可能是东方血统流向印度的桥梁。另一方面，R6基因在尼泊尔人中的存在表明，印度和尼泊尔之间的基因流动是相互的。
We have analyzed 7137 samples from 125 different caste, tribal and religious groups of India and 99 samples from three populations of Nepal for the length variation in the COII/tRNALys region of mtDNA. Samples showing length variation were subjected to detailed phylogenetic analysis based on HVS-I and informative coding region sequence variation. The overall frequencies of the 9-bp deletion and insertion variants in South Asia were 1.8% and 0.5%, respectively. We have also defined a novel deep-rooting haplogroup M43 and identified the rare haplogroup H14 in Indian populations carrying the 9bp-deletion by complete mtDNA sequencing. Moreover, we redefined haplogroup M6 and dissected it into two well-defined subclades. The presence of haplogroups F1 and B5a in Uttar Pradesh suggests minor maternal contribution from Southeast Asia to Northern India. The occurrence of haplogroup F1 in the Nepalese sample implies that Nepal might have served as a bridge for the flow of eastern lineages to India. The presence of R6 in the Nepalese, on the other hand, suggests that the gene flow between India and Nepal has been reciprocal.
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影响因子：
5.3
作者：
Kong, QP;Yao, YG;Zhang, YP
通讯作者：
Zhang, YP
影响因子：
4
作者：
Chaubey, Gyaneshwer;Metspalu, Mait;Villems, Richard
通讯作者：
Villems, Richard
影响因子：
56.9
作者：
Ruiz-Pesini, E;Mishmar, D;Wallace, DC
通讯作者：
Wallace, DC
影响因子：
9.8
作者：
Kivisild, T;Rootsi, S;Villems, R
通讯作者：
Villems, R
影响因子：
3.5
作者：
Fucharoen, G;Fucharoen, S;Horai, S
通讯作者：
Horai, S