Retinal ganglion cell dysfunction in preclinical Alzheimer's disease: an electrophysiologic biomarker signature.
Retinal ganglion cell dysfunction in preclinical Alzheimer's disease: an electrophysiologic biomarker signature.
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DOI：
10.1038/s41598-021-85010-1
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发表时间：
2021-03-18
影响因子：
4.6
通讯作者：
Karanjia R
中科院分区：
文献类型：
--
作者：
Asanad S;Felix CM;Fantini M;Harrington MG;Sadun AA;Karanjia R
本研究使用视网膜电图（ERG）评估了认知健康（CH）的临床前阿尔茨海默病（AD）受试者的视网膜功能，根据脑脊液（CSF）Aβ42/Tau比值进行分类。通过光谱域光学相干断层扫描确定视网膜形态正常的个体被招募。在29名成年受试者（58只眼）中进行了全视野ERG、模式PERG和明视负反应（PhNR）。分析ERG各波的振幅和隐时。与对照组相比，临床前AD参与者显示出明显的视网膜神经节细胞功能障碍。与对照组相比，临床前AD的PhNR显著降低。PhNR振幅和N95隐式时间区分具有AD病理学CSF生物标志物的CH个体，灵敏度为87%，特异性为82%。这些定量的电生理研究结果扩展了我们对AD认知功能下降之前的早期视网膜功能变化的理解。通过ERG检测的视网膜神经节细胞功能障碍可能是用于早期疾病检测的临床上有用的、非侵入性的体内生物标志物，这对于最终追求早期干预是必要的。
The current study evaluated retinal function using electroretinography (ERG) in cognitively healthy (CH) participants with preclinical Alzheimer’s disease (AD), as classified by cerebral spinal fluid (CSF) Aβ42/Tau ratio. Individuals with normal retinal morphology ascertained by spectral-domain optical coherence tomography were enrolled. Full-field ERG, pattern PERG, and photopic negative response (PhNR) were performed in 29 adult participants (58 eyes). Amplitude and implicit times of the ERG wave components were analyzed. Preclinical AD participants showed marked retinal ganglion cell dysfunction relative to controls. The PhNR was significantly diminished in preclinical AD relative to controls. PhNR amplitude and N95 implicit time differentiated CH individuals with CSF biomarkers of AD pathology with 87% sensitivity and 82% specificity. These quantitative electrophysiologic findings expand our understanding of early retinal functional changes that precede cognitive decline in AD. Retinal ganglion cell dysfunction, as detected by ERG, may be a clinically useful, non-invasive in vivo biomarker for early disease detection, which is necessary for ultimately pursuing early intervention.
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影响因子：
5.7
作者：
Koronyo-Hamaoui, Maya;Koronyo, Yosef;Ljubimov, Alexander V.;Miller, Carol A.;Ko, MinHee K.;Black, Keith L.;Schwartz, Michal;Farkas, Daniel L.
通讯作者：
Farkas, Daniel L.
影响因子：
3.7
作者：
Coppola G;Di Renzo A;Ziccardi L;Martelli F;Fadda A;Manni G;Barboni P;Pierelli F;Sadun AA;Parisi V
通讯作者：
Parisi V
影响因子：
11.2
作者：
CURCIO, CA;DRUCKER, DN
通讯作者：
DRUCKER, DN
影响因子：
14
作者：
通讯作者：
--
影响因子：
2.9
作者：
BLANKS, JC;HINTON, DR;MILLER, CA
通讯作者：
MILLER, CA