Immunoglobulin E and mast cell proteases are potential risk factors of impaired fasting glucose and impaired glucose tolerance in humans.
Immunoglobulin E and mast cell proteases are potential risk factors of impaired fasting glucose and impaired glucose tolerance in humans.
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DOI：
10.3109/07853890.2012.732234
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发表时间：
2013-05
影响因子：
4.4
通讯作者：
Shi GP
中科院分区：
文献类型：
--
作者：
Wang Z;Zhang H;Shen XH;Jin KL;Ye GF;Qiu W;Qian L;Li B;Zhang YH;Shi GP
肥大细胞在实验性糖尿病中很重要。血浆免疫球蛋白E(IgE)、类胰蛋白酶和乳糜酶的水平是人类糖尿病的炎症标志物。然而，它们是否也与糖尿病前期的风险相关，目前尚不清楚。260例55~75岁的受试者分为正常糖耐量(NGT)、单纯空腹血糖受损(I-IFG)、单纯糖耐量受损(I-IGT)和IFG/IGT混合型。糖尿病前期各亚组间高敏C反应蛋白(HsCRP)(P=0.001)和Ig E(P=0.003)水平差异有统计学意义，I-IGT(P=0.043)和IFG/IGT混合型(P=0.037)组与NGT组比较，差异有统计学意义。高敏C反应蛋白是糖尿病前期各亚组的危险因素，IgE是混合性IFG/IGT的危险因素，糜酶是I-IGT和IFG/IGT混合性的危险因素。超敏C反应蛋白与高腰围、腰臀比或HOMA-β指数之间的相互作用，以及免疫球蛋白E与高腰围或类胰蛋白酶水平之间的相互作用，都进一步增加了发生I-IFG、I-IGT或混合性IFG/IGT的风险。血浆hsCRP、IgE和糜酶水平与糖尿病前期状态相关。虽然hsCRP、IgE和糜酶是糖尿病前期的单独危险因素，但与代谢参数的相互作用进一步增加了糖尿病前期的风险。
Mast cells are important in experimental diabetes. Plasma levels of immunoglobulin E (IgE), tryptases, and chymases are inflammatory markers of human diabetes. Whether they also correlate with the risk of pre-diabetes, however, remains unknown. A total of 260 subjects 55–75 years of age were grouped as normal glucose tolerance (NGT), isolated impaired fasting glucose (I-IFG), isolated impaired glucose tolerance (I-IGT), and mixed IFG/IGT. There were significant differences in plasma levels of high-sensitivity C-reactive protein (hsCRP) (P < 0.001) and IgE (P=0.003) among all subgroups of pre-diabetes, and chymase in I-IGT (P=0.043) and mixed IFG/IGT (P=0.037) subgroups compared with NGT group. High-sensitivity CRP was a risk factor in all subgroups of pre-diabetes; IgE was a risk factor of mixed IFG/IGT; and chymase was a risk factor of I-IGT and mixed IFG/IGT. Interactions between hsCRP and high waist circumference (WC), waist-to-hip ratio (WHR), or HOMA-β index, and interactions between IgE and high WC or tryptase levels all increased further the risk of developing I-IFG, I-IGT, or mixed IFG/IGT. Plasma hsCRP, IgE, and chymase levels associate with pre-diabetes status. While hsCRP, IgE, and chymase are individual risk factors of pre-diabetes, interactions with metabolic parameters increased further the risk of pre-diabetes.
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DOI：
10.1111/j.1464-5491.2011.03560.x
发表时间：
2012-06
期刊：
Diabetic medicine : a journal of the British Diabetic Association
影响因子：
--
作者：
Cox AJ;Agarwal S;M Herrington D;Carr JJ;Freedman BI;Bowden DW
通讯作者：
Bowden DW
影响因子：
2.8
作者：
Haffner, SM
通讯作者：
Haffner, SM
影响因子：
16.2
作者：
Hanefeld, M;Koehler, C;Temelkova-Kurktschiev, T
通讯作者：
Temelkova-Kurktschiev, T
影响因子：
8.2
作者：
Lee, C. C.;Adler, A. I.;Wareham, N. J.
通讯作者：
Wareham, N. J.
影响因子：
5.8
作者：
Krentz, AJ
通讯作者：
Krentz, AJ