Delphinidin, one of the major anthocyanidins, prevents bone loss through the inhibition of excessive osteoclastogenesis in osteoporosis model mice.
Delphinidin, one of the major anthocyanidins, prevents bone loss through the inhibition of excessive osteoclastogenesis in osteoporosis model mice.
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DOI：
10.1371/journal.pone.0097177
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Niida S
中科院分区：
文献类型：
--
作者：
Moriwaki S;Suzuki K;Muramatsu M;Nomura A;Inoue F;Into T;Yoshiko Y;Niida S
花色苷是一类黄酮类化合物，是水溶性植物色素的大家族，具有广泛的健康促进作用。最近，据报道，蓝莓中富含花青素的化合物对卵巢切除（OVX）动物模型的骨丢失具有保护作用。然而，花青素化合物中的活性成分尚未被鉴定。在这里，我们表明，飞燕草素，浆果中的主要花青素之一，是一种有效的活性成分，通过抑制破骨细胞的形成，在抗骨质疏松性骨吸收。体外实验表明，与其他花青素、矢车菊素和芍药素相比，飞燕草素处理显著抑制RAW 264.7细胞向破骨细胞的分化。在RANKL诱导的骨质疏松模型小鼠和OVX模型小鼠中，经口给予飞燕草素显著防止骨丢失。我们进一步提供了飞燕草素抑制NF-κB、c-fos和Nfatc 1活性的证据，这些因子是破骨细胞生成的主要转录因子。这些结果有力地表明，飞燕草素是破骨细胞分化的最有效的抑制剂，并将成为预防绝经后骨质疏松症骨丢失的有效药物。
Anthocyanins, one of the flavonoid subtypes, are a large family of water-soluble phytopigments and have a wide range of health-promoting benefits. Recently, an anthocyanin-rich compound from blueberries was reported to possess protective property against bone loss in ovariectomized (OVX) animal models. However, the active ingredients in the anthocyanin compound have not been identified. Here we show that delphinidin, one of the major anthocyanidins in berries, is a potent active ingredient in anti-osteoporotic bone resorption through the suppression of osteoclast formation. In vitro examinations revealed that delphinidin treatment markedly inhibited the differentiation of RAW264.7 cells into osteoclasts compared with other anthocyanidins, cyanidin and peonidin. Oral administration of delphinidin significantly prevented bone loss in both RANKL-induced osteoporosis model mice and OVX model mice. We further provide evidence that delphinidin suppressed the activity of NF-κB, c-fos, and Nfatc1, master transcriptional factors for osteoclastogenesis. These results strongly suggest that delphinidin is the most potent inhibitor of osteoclast differentiation and will be an effective agent for preventing bone loss in postmenopausal osteoporosis.
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影响因子：
5.6
作者：
Kim, Tae-Ho;Jung, Ji Won;Kim, Shin-Yoon
通讯作者：
Kim, Shin-Yoon
影响因子：
6.1
作者：
Matsumoto, H;Nakamura, Y;Hirayama, M
通讯作者：
Hirayama, M
影响因子：
3.8
作者：
Hollman, PCH
通讯作者：
Hollman, PCH
影响因子：
6.2
作者：
Tomimori, Yoshiya;Mori, Kaoru;Yasuda, Hisataka
通讯作者：
Yasuda, Hisataka
DOI：
10.1196/annals.1397.055
发表时间：
2007-01-01
期刊：
SIGNAL TRANSDUCTION PATHWAYS, PT C
影响因子：
--
作者：
Kwon, Jung Yeon;Lee, Ki Won;Lee, Hyong Joo
通讯作者：
Lee, Hyong Joo