Mullerian‐inhibiting substance secretion is delayed in XX sex‐reversed dog embryos
Mullerian‐inhibiting substance secretion is delayed in XX sex‐reversed dog embryos
复制标题
XX 性别逆转狗胚胎中苗勒氏管抑制物质的分泌延迟
DOI：
--
复制
发表时间：
1994
影响因子：
2.5
通讯作者：
P. Donahoe
中科院分区：
文献类型：
--
作者：
V. Meyers;D. Maclaughlin;V. L. Palmer;P. Donahoe
支持细胞分泌苗勒管抑制物质（MIS）在睾丸分化后不久开始。胚胎关键期MIS暴露后苗勒管退化。在XX性反转犬中，苗勒管在睾丸组织存在的情况下仍然存在。本研究旨在确定正常男性穆勒管退行期间XX性逆转胚胎的卵睾丸中是否存在MIS。通过核型和性腺组织学的组合鉴定XX个性反转胚胎和正常同窝仔。对邻近苗勒管的消退程度进行评分。免疫组织化学染色检测对侧性腺MIS。睾丸分化和MIS分泌物在XY胚胎在所有年龄的研究（35-46天）。在35-38天（n = 15）之间存在XX性逆转风险的胚胎的性腺中未观察到生精小管，但在40和46天（n = 3）观察到生精小管。尽管在卵睾丸中观察到MIS阳性染色，但邻近的苗勒管持续存在。与正常睾丸相比，卵睾丸生精小管发育程度降低，MIS分泌延迟。苗勒管在该模型中的持续存在显然是由于胚胎发育期间MIS分泌的数量和时间异常。© 1994 Wiley利斯，Inc.
Sertoli cell secretion of Mullerian‐inhibiting substance (MIS) begins shortly after testis differentiation. Mullerian ducts regress following MIS exposure during an embryonic critical period. In dogs with XX sex reversal, Mullerian ducts persist in the presence of testicular tissue. This study was conducted to determine whether MIS is present in ovotestes of XX sex‐reversed embryos during the period for Mullerian duct regression in normal males. XX sex‐reversed embryos and normal littermates were identified by a combination of karyotype and gonadal histology. The degree of regression in the adjacent Mullerian duct was scored. Immunohistochemical staining was used to detect MIS in the contralateral gonad. Testicular differentiation and MIS secretion were identified in XY embryos at all ages studied (35–46 days). Seminiferous tubules were not observed in gonads of embryos at risk of XX sex reversal between 35–38 days (n = 15), but were observed at 40 and 46 days (n = 3). Although positive staining for MIS was observed in ovotestes, adjacent Mullerian ducts persisted. The degree of seminiferous tubule development was reduced and MIS secretion was delayed in ovotestes, compared to normal testes. Mullerian duct persistence in this model is apparently due to an abnormality in the quantity and timing of MIS secretion during embryonic development.© 1994 Wiley‐Liss, Inc.
登录
查看更多内容
苗勒管抑制物质信使核糖核酸在颗粒细胞和支持细胞中的表达与其有丝分裂活性一致。
影响因子：
4.8
作者：
Hirobe,S;He,WW;Lee,MM;Donahoe,PK
通讯作者：
Donahoe,PK
影响因子：
4.8
作者：
Shigeru Ueno;Tatsuo Kuroda;D. Maclaughlin;R. Ragin;T. Manganaro;P. K. Donahoe
通讯作者：
Shigeru Ueno;Tatsuo Kuroda;D. Maclaughlin;R. Ragin;T. Manganaro;P. K. Donahoe
通过苗勒管抑制物质的免疫细胞化学染色证明 B6.YDOM 卵睾中睾丸分化的延迟。
影响因子：
2.7
作者：
Taketo,T;Saeed,J;Nishioka,Y;Donahoe,PK
通讯作者：
Donahoe,PK
性别决定区 Y 基因在 46,XX 男性病因学中的作用。
DOI：
10.1210/jcem.76.3.8383144
发表时间：
1993
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Fechner,PY;Marcantonio,SM;Jaswaney,V;Stetten,G;Goodfellow,PN;Migeon,CJ;Smith,KD;Berkovitz,GD;Amrhein,JA;Bard,PA
通讯作者：
Bard,PA
性逆转狗中的苗勒氏管抑制物质。
影响因子：
3.6
作者：
Meyers-Wallen,VN;Donahoe,PK;Manganaro,T;Patterson,DF
通讯作者：
Patterson,DF