Impact of obesity on development and progression of mammary tumors in preclinical models of breast cancer.
Impact of obesity on development and progression of mammary tumors in preclinical models of breast cancer.
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DOI：
10.1007/s10911-013-9300-x
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发表时间：
2013-12
影响因子：
2.5
通讯作者：
Cleary, Margot P.
中科院分区：
文献类型：
--
作者：
Cleary, Margot P.
关键词：
超重和/或肥胖是绝经后乳腺癌的已知危险因素。最近，体重增加也与绝经前和绝经后乳腺癌的不良预后相关。这种关系主要是通过流行病学研究确定的。来自体外研究的更多信息也已产生，试图描绘肥胖和体重与乳腺癌之间关联的作用机制。这种方法已经确定了潜在的生长因子，如胰岛素、瘦素、雌激素和 IGF-I，据报道这些因子可通过体重变化进行调节。然而，体外研究范围有限，并且经常使用非生理浓度的生长因子，而人体研究需要长期随访。临床前动物模型提供了一种中间方法来研究体重和潜在生长因子对乳腺肿瘤发生和进展的影响。这里介绍了解决这个问题的许多研究的结果。在大多数研究中，遗传肥胖或饮食诱导的肥胖啮齿动物模型已被用于研究自发性、转基因和致癌物诱导的乳腺肿瘤的发展。为了研究肿瘤进展，主要焦点是对遗传或饮食引起的肥胖小鼠进行同种异体移植研究。一般来说，肥胖已被证明可以缩短乳腺肿瘤潜伏期并影响肿瘤病理学。然而，对于瘦素和其他生长因子存在缺陷的啮齿动物来说，肥胖的影响并不那么直接。未来的研究使用更多生理相关的肥胖模型，并明确区分饮食成分与体重影响，对于继续了解体重对乳腺癌发生和进展影响的相关因素非常重要。
Overweight and/or obesity are known risk factors for postmenopausal breast cancer. More recently increased body weight has also been associated with poor prognosis for both pre- and postmenopausal breast cancer. This relationship has primarily been identified through epidemiological studies. Additional information from in vitro studies has also been produced in attempts to delineate mechanisms of action for the association of obesity and body weight and breast cancer. This approach has identified potential growth factors such as insulin, leptin, estrogen and IGF-I which are reported to be modulated by body weight changes. However, in vitro studies are limited in scope and frequently use non-physiological concentrations of growth factors, while long follow-up is needed for human studies. Preclinical animal models provide an intermediary approach to investigate the impact of body weight and potential growth factors on mammary/breast tumor development and progression. Here results of a number of studies addressing this issue are presented. In the majority of the studies either genetically-obese or diet-induced obese rodent models have been used to investigate spontaneous, transgenic and carcinogen-induced mammary tumor development. To study tumor progression the major focus has been allograft studies in mice with either genetic or dietary-induced obesity. In general, obesity has been demonstrated to shorten mammary tumor latency and to impact tumor pathology. However, in rodents with defects in leptin and other growth factors the impact of obesity is not as straightforward. Future studies using more physiologically relevant obesity models and clearly distinguishing diet composition from body weight effects will be important in continuing to understand the factors associated with body weight’s impact on the mammary/breast cancer development and progression.
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肥胖可促进雌性扎克大鼠蒽诱导的乳腺肿瘤发育的7,12-二甲基苯子。
DOI：
10.1186/bcr1263
发表时间：
2005
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Hakkak R;Holley AW;Macleod SL;Simpson PM;Fuchs GJ;Jo CH;Kieber-Emmons T;Korourian S
通讯作者：
Korourian S
DOI：
10.1111/j.1939-1676.1998.tb02108.x
发表时间：
1998-05-01
影响因子：
2.6
作者：
Alenza, DP;Rutteman, GR;Cuesta, P
通讯作者：
Cuesta, P
影响因子：
4.9
作者：
Cleary, MP;Grande, JP;Maihle, NJ
通讯作者：
Maihle, NJ
影响因子：
2.9
作者：
Cleary, MP;Grande, JP;Maihle, NJ
通讯作者：
Maihle, NJ
影响因子：
7.4
作者：
Dogan, Soner;Hu, Xin;Cleary, Margot P.
通讯作者：
Cleary, Margot P.