Evidence for two distinct thalamocortical circuits in retrosplenial cortex
Evidence for two distinct thalamocortical circuits in retrosplenial cortex
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压后皮质有两个不同丘脑皮质回路的证据
DOI：
10.1101/2021.06.11.448056
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发表时间：
2021
影响因子：
2.7
通讯作者：
K. Jeffery
中科院分区：
文献类型：
--
作者：
Eleonora Lomi;M. L. Mathiasen;H. Y. Cheng;Ningyu Zhang;J. Aggleton;Anna S. Mitchell;K. Jeffery
压后皮层 (RSC) 位于大脑中感知网络和记忆网络之间的界面，并在这两者之间进行调解，尽管目前尚不清楚如何进行调解。它有两个不同的子区域：颗粒状 (gRSC) 和颗粒状 (dRSC)。本研究调查了这些子区域在电生理学和连接方面的差异，作为理解其功能的一步。 gRSC与海马系统的联系更为密切，其中θ带局部场电位振荡较为突出。因此，我们比较了两个 RSC 亚区之间的 θ 节律单单元活动，发现主要在 gRSC 中，一个非定向细胞亚群，其尖峰活动受到 θ 振荡的强烈影响，表明 gRSC 与海马系统有更强的耦合。然后，我们使用逆行示踪剂来检查 RSC 亚区之间神经编码的差异是否可能反映来自前丘脑的差异输入，前丘脑是 RSC 传入的重要来源。我们发现 gRSC 和 dRSC 的传入神经来自两个 AV 亚域：背内侧 (AVDM) 和腹外侧 (AVVL)。 AVVL 以 gRSC 和 dRSC 为目标，而 AVDM 则提供对 gRSC 的选择性投影。这些综合结果表明存在两个不同但相互作用的 RSC 子电路：一个将 AVDM 连接到可能构成认知海马系统一部分的 gRSC，另一个将 AVVL 连接到可能连接海马和感知区域的两个 RSC 区域。我们认为这些子电路是不同的，以便在融合感觉和认知计算的整合过程中允许不同的权重：整合可能发生在丘脑、RSC 或两者中。亮点 • 压后皮层两个亚区域，gRSC 和dRSC，其时间放电特征和与θ 振荡的关系不同。 • 从丘脑前腹核到gRSC 和dRSC 的传入神经存在差异，背内侧亚核选择性地投射到gRSC。因此，丘脑前腹-压后皮层回路包含两个功能和解剖学上不同但相连的回路，它们与海马系统有差异地连接，这可能支持认知和知觉信息的整合。
Retrosplenial cortex (RSC) lies at the interface between perceptual and memory networks in the brain and mediates between these, although it is not yet known how. It has two distinct subregions, granular (gRSC) and dysgranular (dRSC). The present study investigated how these subregions differ with respect to their electrophysiology and connections, as a step towards understanding their functions. gRSC is more closely connected to the hippocampal system, in which theta-band local field potential oscillations are prominent. We therefore compared theta-rhythmic single-unit activity between the two RSC subregions and found, mostly in gRSC, a subpopulation of non-directional cells with spiking activity strongly entrained by theta oscillations, suggesting a stronger coupling of gRSC to the hippocampal system. We then used retrograde tracers to examine whether differences in neural coding between RSC subregions might reflect differential inputs from the anterior thalamus, which is a prominent source of RSC afferents. We found that gRSC and dRSC differ in their afferents from two AV subfields: dorsomedial (AVDM) and ventrolateral (AVVL). AVVL targets both gRSC and dRSC, while AVDM provides a selective projection to gRSC. These combined results suggest the existence of two distinct but interacting RSC subcircuits: one connecting AVDM to gRSC that may comprise part of the cognitive hippocampal system, and the other connecting AVVL to both RSC regions that may link hippocampal and perceptual regions. We suggest that these subcircuits are distinct to allow for differential weighting during integration of converging sensory and cognitive computations: an integration that may take place in thalamus, RSC or both. Highlights • The two retrosplenial cortex subregions, gRSC and dRSC, differ in their temporal firing characteristics and relation to theta oscillations. • There are differential afferents from the anteroventral thalamic nucleus to gRSC and dRSC, with the dorsomedial subnucleus projecting selectively to gRSC. • The anteroventral thalamus-retrosplenial cortex circuitry thus comprises two functionally and anatomically distinct but connected circuits, differentially connected to the hippocampal system, that may support the integration of cognitive and perceptual information.
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影响因子：
2.5
作者：
MCCORMICK, DA;CONNORS, BW;PRINCE, DA
通讯作者：
PRINCE, DA
影响因子：
2.5
作者：
Frank, LM;Brown, EN;Wilson, MA
通讯作者：
Wilson, MA
头部方向、位置和运动与大鼠压后皮质细胞相关。
影响因子：
1.9
作者：
Cho,J;Sharp,PE
通讯作者：
Sharp,PE
影响因子：
2.5
作者：
Henze, DA;Borhegyi, Z;Buzsáki, G
通讯作者：
Buzsáki, G
海马体的 Theta 节律：皮层下控制和功能意义。
DOI：
10.1177/1534582304273594
发表时间：
2004
期刊：
Behavioral and cognitive neuroscience reviews.
影响因子：
--
作者：
Vertes,RobertP;Hoover,WalterB;VianaDiPrisco,Gonzalo
通讯作者：
VianaDiPrisco,Gonzalo