The importance of studying sex differences in disease: The example of multiple sclerosis.
The importance of studying sex differences in disease: The example of multiple sclerosis.
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DOI：
10.1002/jnr.23955
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发表时间：
2017-01-02
影响因子：
4.2
通讯作者：
Voskuhl R
中科院分区：
文献类型：
--
作者：
Golden LC;Voskuhl R
迄今为止，科学研究通常集中在一种性别上，并假设对另一种性别的研究也会产生类似的结果。然而，许多疾病对男性和女性的影响不同。患者的性别可以影响疾病易感性或进展的风险。这些差异可以带到实验室进行研究，有可能将新的治疗方法带回临床。这种研究方法被称为“床边到工作台到床边”的方法，已被应用于研究多发性硬化症（MS）的性别差异。女性更容易患多发性硬化症，而男性病情进展较差。这种疾病的这两个特征分别受到免疫系统和神经系统的影响。因此，必须研究每个系统中的性别差异。个性化医疗最近一直处于研究的前沿，研究疾病的性别差异符合这一倡议。这篇综述将讨论已知的多发性硬化症的性别差异，并强调如何研究这些差异可以为男性和女性带来新的见解和潜在的治疗方法。
To date, scientific research has often focused on one sex, with assumptions that study of the other sex would yield similar results. However, many diseases affect males and females differently. The sex of a patient can affect the risk for disease susceptibility or progression by fold differences. Such differences can be brought to the laboratory bench to be investigated, potentially bringing new treatments back to the clinic. This method of research, known as a “bedside to bench to bedside” approach has been applied to studying sex differences in multiple sclerosis (MS). Females have greater susceptibly to MS, while males have worse disease progression. These two characteristics of the disease are influenced by the immune system and the nervous system, respectively. Thus, sex differences in each system must be studied. Personalized medicine has been at the for-front of research recently, and studying sex differences in disease fits with this initiative. This review will discuss the known sex differences in MS and highlight how investigating them can lead to new insights and potential treatments for both men and women.
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