Photobiomodulation for traumatic brain injury and stroke.
Photobiomodulation for traumatic brain injury and stroke.
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DOI：
10.1002/jnr.24190
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发表时间：
2018-04
影响因子：
4.2
通讯作者：
Hamblin MR
中科院分区：
文献类型：
--
作者：
Hamblin MR
创伤性脑损伤（TBI）正在迅速成为一种全球流行病，但明显缺乏治疗替代品。光生物调节（PBM）采用红色或近红外（NIR）光（600- 1100 nm）来刺激愈合，保护组织免于死亡，增加线粒体功能，改善血流和组织氧合。PBM还可以起到减少肿胀、增加抗氧化剂、减少炎症、防止细胞凋亡和调节小胶质细胞活化状态的作用。所有这些作用机制强烈表明，在急性和慢性TBI的情况下，递送至头部的PBM应该是有益的。大多数报告使用来自激光器或发光二极管（LED）的近红外光。在急性TBI的小动物模型中进行的许多研究已经发现了对神经功能，学习和记忆的积极影响，并减少了大脑中的炎症和细胞死亡。有证据表明，PBM可以通过刺激神经发生，上调BDNF合成和促进突触发生来帮助大脑自我修复。在健康的人类志愿者（包括学生和健康的老年妇女）中，PBM已被证明可以增加局部脑血流量，组织氧合，改善记忆，情绪和认知功能。已经在患有TBI慢性效应的患者中进行了临床研究。有报告称，执行功能，工作记忆和睡眠改善。功能性磁共振成像已经显示了可能在TBI中受损的内在脑网络（默认模式网络和显着网络）中的激活调制。
There is a notable lack of therapeutic alternatives for what is fast becoming a global epidemic of traumatic brain injury (TBI). Photobiomodulation (PBM) employs red or near-infrared (NIR) light (600-1100nm) to stimulate healing, protect tissue from dying, increase mitochondrial function, improve blood flow and tissue oxygenation. PBM can also act to reduce swelling, increase antioxidants, decrease inflammation, protect against apoptosis, and modulate microglial activation state. All these mechanisms of action strongly suggest that PBM delivered to the head should be beneficial in cases of both acute and chronic TBI. Most reports have used NIR light either from lasers or from light-emitting diodes (LEDs). Many studies in small animal models of acute TBI have found positive effects on neurological function, learning and memory, and reduced inflammation and cell death, in the brain. There is evidence that PBM can help the brain to repair itself by stimulating neurogenesis, upregulating BDNF synthesis, and encouraging synaptogenesis. In healthy human volunteers (including students and healthy elderly women) PBM has been shown to increase regional cerebral blood flow, tissue oxygenation and improve memory, mood and cognitive function. Clinical studies have been conducted in patients suffering from the chronic effects of TBI. There have been reports of improvements in executive function, working memory, and improved sleep. Functional magnetic resonance imaging has shown modulation of activation in intrinsic brain networks likely to be damaged in TBI (default mode network and salience network).
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DOI：
10.1016/j.bbacli.2016.09.002
发表时间：
2016-12
期刊：
BBA clinical
影响因子：
--
作者：
Hamblin, Michael R
通讯作者：
Hamblin, Michael R
影响因子：
2.2
作者：
Blanco NJ;Maddox WT;Gonzalez-Lima F
通讯作者：
Gonzalez-Lima F
影响因子：
6.3
作者：
Dong, Tingting;Zhang, Qi;Wu, Mei X.
通讯作者：
Wu, Mei X.
影响因子：
81.5
作者：
Blennow, Kaj;Brody, David L.;Zetterberg, Henrik
通讯作者：
Zetterberg, Henrik
影响因子：
3.1
作者：
Dirican, Abuzer;Andacoglu, Oya;Soran, Atilla
通讯作者：
Soran, Atilla