Inhibition by gastrin-releasing peptide of growth hormone (GH) secretion induced by human pancreatic GH-releasing factor in rats.
Inhibition by gastrin-releasing peptide of growth hormone (GH) secretion induced by human pancreatic GH-releasing factor in rats.
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胃泌素释放肽对人胰腺 GH 释放因子诱导的大鼠生长激素 (GH) 分泌的抑制作用。
DOI：
10.1210/endo-115-2-649
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发表时间：
1984
期刊：
影响因子：
4.8
通讯作者：
H. Imura
中科院分区：
文献类型：
--
作者：
Y. Kabayama;Y. Kato;A. Shimatsu;H. Ohta;N. Yanaihara;H. Imura
Intravenous injection of synthetic human pancreatic GH-releasing factor (1-44) [hpGRF(1-44)] (50 ng-1 micrograms/100 g BW) resulted in a dose-related increase in plasma GH levels in urethane-anesthetized male rats. Pretreatment with cysteamine (30 mg/100 g BW, sc, 4 h previously) or anti-SRIF rabbit serum (0.5 ml/rat, iv, 1 h previously) raised basal plasma GH levels and markedly exaggerated the plasma GH response to hpGRF (1-44) (80 ng/100 g BW, iv). The intraventricular injection of gastrin-releasing peptide (GRP) (1 micrograms/rat) completely inhibited the increase of plasma GH induced by hpGRF (80 ng/100 g BW, iv) in control rats. However, in the rats treated with cysteamine or anti-SRIF rabbit serum, the inhibitory effect of GRP on hpGRF-induced GH release was significantly attenuated. hpGRF (10(-11)-10(-8) M) stimulated in a dose-related manner GH release from rat anterior pituitary cells superfused in vitro. GRP (10(-5) M) did not affect pituitary GH release induced by hpGRF (10(-9) M) in vitro. These results indicate that hpGRF stimulates rat GH secretion by acting at the pituitary level and the hypothalamic SRIF interacts with the action of GRF, and that GRP inhibits GH secretion, at least in part, by stimulating SRIF release from the hypothalamus.
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影响因子：
56.9
作者：
GUILLEMIN, R;BRAZEAU, P;WEHRENBERG, WB
通讯作者：
WEHRENBERG, WB
合成人胰腺（肿瘤）GH 释放因子和生长抑素、三碘甲腺原氨酸和地塞米松对体外 GH 分泌的影响。
影响因子：
4.8
作者：
Vale,W;Vaughan,J;Yamamoto,G;Spiess,J;Rivier,J
通讯作者：
Rivier,J
半胱胺对雄性大鼠生长激素分泌的影响。
影响因子：
4.8
作者：
Millard,WJ;Sagar,SM;Badger,TM;Martin,JB
通讯作者：
Martin,JB
生长激素分泌素和生长抑素在调节生长激素分泌中的生理作用。
DOI：
10.1016/0006-291x(82)91758-2
发表时间：
1982
影响因子：
3.1
作者：
Wehrenberg,WB;Ling,N;Böhlen,P;Esch,F;Brazeau,P;Guillemin,R
通讯作者：
Guillemin,R
给予半胱胺可耗尽大鼠组织中的生长抑素。
影响因子：
4.8
作者：
Szabo,S;Reichlin,S
通讯作者：
Reichlin,S