Complex I from the fungus Neurospora crassa.

Complex I from the fungus Neurospora crassa.
复制标题

来自真菌粗糙脉孢菌的复合物 I。

DOI:
10.1016/s0005-2728(98)00020-6
复制
发表时间:
1998
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
A. Videira
A. Videira
中科院分区:
--
文献类型:
--
作者:
A. Videira

文献摘要

参考文献

被引文献

相似文献

呼吸链复合物I是线粒体中一种复杂的酶,它将电子从NADH转移到泛醌,再到质子穿过细胞器内膜的转运偶联起来。粗糙脉孢菌是研究该酶的主要模式生物之一。复合物I由双重遗传来源的多个多肽亚基组成,并含有参与其活性的几个辅基。大多数亚基已被克隆,那些结合氧化还原中心已被确定。然而,某些复合物I蛋白的功能作用仍然未知。深入了解可能的起源和复杂的I组装的机制已经获得。几株N.其中复合物I的特定亚基被破坏的crassa已经被分离和表征。本文综述了复合物I的结构、功能和生物起源等方面的研究进展。
Respiratory chain complex I is a complicated enzyme of mitochondria, that couples electron transfer from NADH to ubiquinone to the proton translocation across the inner membrane of the organelle. The fungus Neurospora crassa has been used as one of the main model organisms to study this enzyme. Complex I is composed of multiple polypeptide subunits of dual genetic origin and contains several prosthetic groups involved in its activity. Most subunits have been cloned and those binding redox centres have been identified. Yet, the functional role of certain complex I proteins remains unknown. Insight into the possible origin and the mechanisms of complex I assembly has been gained. Several mutant strains of N. crassa, in which specific subunits of complex I were disrupted, have been isolated and characterised. This review concerns many aspects of the structure, function and biogenesis of complex I that are being elucidated.
DNA 序列重复会触发粗糙脉孢菌中的基因失活。
DOI: 10.1073/pnas.85.18.6870
发表时间: 1988
影响因子: 11.1
作者:
Selker,EU;Garrett,PW
通讯作者: Garrett,PW
DOI: 10.1111/j.1432-1033.1994.tb18655.x
发表时间: 1994-03-01
期刊: EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子: --
作者:
FECKE, W;SLED, VD;WEISS, H
通讯作者: WEISS, H
脱氮副球菌能量转导 NADH-泛醌氧化还原酶 25 千道尔顿铁硫亚基的表达。
DOI: 10.1021/bi00168a014
发表时间: 1994
期刊: Biochemistry
影响因子: 2.9
作者:
Yano,T;Sled,VD;Ohnishi,T;Yagi,T
通讯作者: Yagi,T
鼠伤寒沙门氏菌的能量守恒 NADH 脱氢酶有缺陷,通过碳饥饿后能量依赖性蛋白水解的减少来鉴定。
DOI: 10.1073/pnas.90.21.9877
发表时间: 1993
影响因子: 11.1
作者:
Archer,CD;Wang,X;Elliott,T
通讯作者: Elliott,T
DOI: 10.1111/j.1432-1033.1988.tb14005.x
发表时间: 1988-04-15
期刊: EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子: --
作者:
BRODY, S;MIKOLAJCZYK, S
通讯作者: MIKOLAJCZYK, S