Cumulative association of obstructive sleep apnea severity and short sleep duration with the risk for hypertension.
Cumulative association of obstructive sleep apnea severity and short sleep duration with the risk for hypertension.
复制标题
DOI：
10.1371/journal.pone.0115666
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
IRSR sleep cohort group
中科院分区：
文献类型：
--
作者：
Priou P;Le Vaillant M;Meslier N;Paris A;Pigeanne T;Nguyen XL;Alizon C;Bizieux-Thaminy A;Leclair-Visonneau L;Humeau MP;Gagnadoux F;IRSR sleep cohort group
阻塞性睡眠呼吸暂停（OSA）和睡眠时间短与高血压（HTN）风险增加有关。这项多中心横断面研究的目的是检验OSA严重程度和睡眠时间短与HTN患病风险的累积相关性的假设。在1,499例因疑似OSA接受多导睡眠图检查的患者中，410例（27.3%）既往诊断为高血压并服用降压药物的患者被认为患有HTN。总睡眠时间（TST）<6 h者为短睡眠者。Logistic回归分析确定HTN与OSA和睡眠时间的独立相关性。考虑到正常睡眠者（TST ≥6 h）无OSA为参照组，比值比（OR）（95%置信区间）为2.51正常睡眠OSA组为1.35-4.68，（2.18-8.78）在调整年龄、性别、肥胖、糖尿病、抑郁、目前吸烟、甲状腺激素使用后，白天嗜睡、睡眠不佳、卧床时间、睡眠结构和碎片以及研究地点。HTN的风险似乎与OSA严重程度和睡眠时间短存在累积相关性（线性趋势p<0.0001）。睡眠时间短、睡眠呼吸暂停指数（AHI）≥30的重度阻塞性睡眠呼吸暂停患者发生高血压的危险性更高（OR，4.29 [2.03-9.07]）。在疑似OSA的患者中，睡眠呼吸障碍的严重程度和睡眠时间短与HTN的患病风险有累积相关性。需要进一步的研究来确定优化睡眠的干预措施是否有助于降低OSA患者的血压。
Obstructive sleep apnea (OSA) and short sleep duration are individually associated with an increased risk for hypertension (HTN). The aim of this multicenter cross-sectional study was to test the hypothesis of a cumulative association of OSA severity and short sleep duration with the risk for prevalent HTN. Among 1,499 patients undergoing polysomnography for suspected OSA, 410 (27.3%) previously diagnosed as hypertensive and taking antihypertensive medication were considered as having HTN. Patients with total sleep time (TST) <6 h were considered to be short sleepers. Logistic regression procedures were performed to determine the independent association of HTN with OSA and sleep duration. Considering normal sleepers (TST ≥6 h) without OSA as the reference group, the odds ratio (OR) (95% confidence intervals) for having HTN was 2.51 (1.35–4.68) in normal sleepers with OSA and 4.37 (2.18–8.78) in short sleepers with OSA after adjustment for age, gender, obesity, diabetes, depression, current smoking, use of thyroid hormones, daytime sleepiness, poor sleep complaint, time in bed, sleep architecture and fragmentation, and study site. The risk for HTN appeared to present a cumulative association with OSA severity and short sleep duration (p<0.0001 for linear trend). The higher risk for HTN was observed in short sleepers with severe OSA (AHI ≥30) (OR, 4.29 [2.03–9.07]). In patients investigated for suspected OSA, sleep-disordered breathing severity and short sleep duration have a cumulative association with the risk for prevalent HTN. Further studies are required to determine whether interventions to optimize sleep may contribute to lower BP in patients with OSA.
登录
查看更多内容
影响因子：
--
作者：
Bixler, EO;Vgontzas, AN;Kales, A
通讯作者：
Kales, A
影响因子：
5.6
作者：
Knutson, Kristen L.;Van Cauter, Eve;Lauderdale, Diane S.
通讯作者：
Lauderdale, Diane S.
影响因子：
3.2
作者：
Lusardi, P;Mugellini, A;Fogari, R
通讯作者：
Fogari, R
DOI：
10.1001/jama.2012.3418
发表时间：
2012-05-23
期刊：
JAMA
影响因子：
--
作者：
Marin JM;Agusti A;Villar I;Forner M;Nieto D;Carrizo SJ;Barbé F;Vicente E;Wei Y;Nieto FJ;Jelic S
通讯作者：
Jelic S
影响因子：
120.7
作者：
Nieto, FJ;Young, TB;Pickering, TG
通讯作者：
Pickering, TG