GPCRDB: an information system for G protein-coupled receptors.
GPCRDB: an information system for G protein-coupled receptors.
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DOI：
10.1093/nar/gkt1255
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发表时间：
2014-01
影响因子：
14.9
通讯作者：
Gloriam D
中科院分区：
文献类型：
--
作者：
Isberg V;Vroling B;van der Kant R;Li K;Vriend G;Gloriam D
在过去的20年里，GPCRDB（G蛋白偶联受体数据库; http：//www.gpcr.org/7tm/）一直是G蛋白偶联受体（GPCR）相关数据的“一站式商店”。GPCRDB包含关于序列、配体结合常数、突变和寡聚体的实验数据，以及许多不同类型的计算衍生数据，例如多重序列比对和同源性模型。GPCRDB还提供可视化和分析工具，以及许多查询系统。在最新的GPCRDB版本中，由于最近一系列的GPCR X射线结构数据，所有多序列比对和> 65000个同源性模型都得到了显着改进。工具被引入到浏览X射线结构，比较结合位点，配置文件相似的受体和生成氨基酸保守统计。蛇图和螺旋盒图现在可以自定义着色（例如通过化学性质或突变数据）并保存为图形。添加了一系列序列比对可视化工具，现在可以为序列和序列位置的子集创建序列比对，并且可以为任何这些子集生成比对统计数据。
For the past 20 years, the GPCRDB (G protein-coupled receptors database; http://www.gpcr.org/7tm/) has been a ‘one-stop shop’ for G protein-coupled receptor (GPCR)-related data. The GPCRDB contains experimental data on sequences, ligand-binding constants, mutations and oligomers, as well as many different types of computationally derived data, such as multiple sequence alignments and homology models. The GPCRDB also provides visualization and analysis tools, plus a number of query systems. In the latest GPCRDB release, all multiple sequence alignments, and >65 000 homology models, have been significantly improved, thanks to a recent flurry of GPCR X-ray structure data. Tools were introduced to browse X-ray structures, compare binding sites, profile similar receptors and generate amino acid conservation statistics. Snake plots and helix box diagrams can now be custom coloured (e.g. by chemical properties or mutation data) and saved as figures. A series of sequence alignment visualization tools has been added, and sequence alignments can now be created for subsets of sequences and sequence positions, and alignment statistics can be produced for any of these subsets.
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影响因子：
5.7
作者：
Kufareva, Irina;Rueda, Manuel;Katritch, Vsevolod;Stevens, Raymond C.;Abagyan, Ruben;Yoshikawa, Yasushi;Furuya, Toshio;Lee, Huisun;Roy, Ambrish;Grime, John;Rebehmed, Joseph;Zhang, Yang;Roumen, Luc;de Esch, Iwan J. P.;Leurs, Rob;de Graaf, Chris;Li, Youyong;Hou, Tingjun;Mysinger, Michael M.;Weiss, Dahlia R.;Irwin, John J.;Shoichet, Brian K.;McRobb, Fiona M.;Capuano, Ben;Crosby, Ian T.;Chalmers, David K.;Yuriev, Elizabeth;Wang, Qi;Mach, Robert H.;Reichert, David E.;Chuang, Gwo-Yu;Rognan, Didier;Simms, John;Sexton, Patrick;Wootten, Denise;Latek, Dorota;Ghoshdastider, Umesh;Filipek, Slawomir;Kirkpatrick, Andrea;Trzaskowski, Bartosz;Griffith, Adam;Kim, Soo-Kyung;Abrol, Ravinder;Goddard, William A., III;Vaidehi, Nagarajan;Lam, Alfonso;Bhattacharya, Supriyo;Li, Hubert;Balaraman, Gouthaman;Niesen, Michiel;Pal, Sandeep;Vorobjev, Yrii;Bakulina, Natalia;Solovyev, Victor;Beuming, Thijs;Costanzi, Stefano;Shi, Lei;Higgs, Chris;Salam, Noeris;Lupyan, Dmitry;Sherman, Woody;Ding, Feng;Kota, Pradeep;Ramachandran, Srinivas;Dokholyan, Nikolay V.;Carlsson, Jens;Coleman, Ryan G.;Fan, Hao;Schlessinger, Avner;Sali, Andrej;Tikhonova, Irina;Pogozheva, Irina;Lomize, Andrei;Hall, Nathan E.;Muddassar, Muhammad;Zhang, Yang;Pae, Ae Nim;Lee, Jooyoung;Lopez, Laura;Obiol-Pardo, Cristian;Selent, Jana;Mahboob, Sadia;Werner, Tim;Church, W. Bret;Brylinski, Michal;Ando, Tadashi;Guerler, Aysam;Zhou, Hongyi;Skolnick, Jeffrey;Xhaard, Henri;Jurkowski, Wiktor;Elofsson, Arne;Murad, Ahsan K.;Drwal, Malgorzata;Dupree, Tom B.;Griffith, Renate;Ostopovici-Halip, Liliana;Bologa, Cristian;Chen, K. M.;Sun, J.;Barth, Patrick;Yarov-Yarovoy, Vladimir;Baker, David;Vroling, Bas;Sanders, Marijn P. A.;Nabuurs, Sander B.;Nikiforovich, Gregory V.
通讯作者：
Nikiforovich, Gregory V.
影响因子：
14.9
作者：
Vroling B;Sanders M;Baakman C;Borrmann A;Verhoeven S;Klomp J;Oliveira L;de Vlieg J;Vriend G
通讯作者：
Vriend G
影响因子：
14.9
作者：
Horn, F;Bettler, E;Vriend, G
通讯作者：
Vriend, G
影响因子：
14.9
作者：
Horn, F;Weare, J;Vriend, G
通讯作者：
Vriend, G
影响因子：
14.9
作者：
Horn, F;Vriend, G;Cohen, FE
通讯作者：
Cohen, FE