Regulation of Drosophila Hematopoiesis in Lymph Gland: From a Developmental Signaling Point of View
Regulation of Drosophila Hematopoiesis in Lymph Gland: From a Developmental Signaling Point of View
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果蝇淋巴腺造血的调节：从发育信号的角度来看
DOI：
10.3390/ijms21155246
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发表时间：
2020-07
影响因子：
5.6
通讯作者：
Ying Su
中科院分区：
文献类型：
--
作者：
Wenwen Lan;Sumin Liu;Long Zhao;Ying Su
果蝇造血系统由于其简单的血细胞谱系及其与脊椎动物系统的发育和功能相似而变得越来越有吸引力。淋巴腺是果蝇幼虫造血的专用器官，它既含有多能干细胞样祖细胞，又含有分化的血细胞。必须精确和严格地控制淋巴腺中祖细胞维持和分化之间的平衡。多种发育信号通路，如Notch、Hedgehog和Wnt/Wingless，已被证明调节淋巴腺中的造血过程。本文以血细胞的维持和分化为重点，综述了几种经典的发育信号通路在淋巴腺发育和形成模式中的作用，强调了发育信号通路在淋巴腺发育和果蝇幼虫造血中的重要作用。
The Drosophila hematopoietic system is becoming increasingly attractive for its simple blood cell lineage and its developmental and functional parallels with the vertebrate system. As the dedicated organ for Drosophila larval hematopoiesis, the lymph gland harbors both multipotent stem-like progenitor cells and differentiated blood cells. The balance between progenitor maintenance and differentiation in the lymph gland must be precisely and tightly controlled. Multiple developmental signaling pathways, such as Notch, Hedgehog, and Wnt/Wingless, have been demonstrated to regulate the hematopoietic processes in the lymph gland. Focusing on blood cell maintenance and differentiation, this article summarizes the functions of several classic developmental signaling pathways for lymph gland growth and patterning, highlighting the important roles of developmental signaling during lymph gland development as well as Drosophila larval hematopoiesis.
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影响因子：
9.2
作者：
Milton, Claire C.;Grusche, Felix A.;Degoutin, Joffrey L.;Yu, Eefang;Dai, Qi;Lai, Eric C.;Harvey, Kieran F.
通讯作者：
Harvey, Kieran F.
影响因子：
2
作者：
R. Dmochowski
通讯作者：
R. Dmochowski
影响因子：
7.7
作者：
Dey NS;Ramesh P;Chugh M;Mandal S;Mandal L
通讯作者：
Mandal L