Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study.
Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study.
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DOI：
10.1186/s12890-021-01611-6
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发表时间：
2021-07-22
影响因子：
3.1
通讯作者：
Dodd JW
中科院分区：
文献类型：
--
作者：
Higbee DH;Granell R;Hemani G;Smith GD;Dodd JW
观察性研究表明肺功能下降与认知受损之间存在关联。认知功能障碍会影响重要的健康结果，并且是痴呆症的先兆，但目前的治疗选择非常有限。因此，人们的注意力集中在识别可改变的风险因素上，以防止认知能力下降并保持认知能力。我们的目标是使用孟德尔随机化 (MR) 确定肺功能或 COPD 风险是否会导致认知功能下降。 来自肺功能和 COPD 的全基因组关联研究的单核苷酸多态性被用作暴露。我们以 132,452 名个体为样本，研究了它们对一般认知功能的影响。然后，我们进行了多变量 MR (MVMR)，检查协变量调节前后肺功能的影响。 我们仅发现微弱的证据表明肺功能降低（Beta − 0.002 (SE 0.02)，p 值 0.86）或 COPD 易感性增加（− 0.008 (0.008)，p 值 0.35）会导致认知功能降低。 MVMR 发现 FEV1 和 FVC 降低确实会导致认知功能降低，但在调节身高（FEV1 和 FVC 分别为 - 0.03 (0.03)、p 值 0.29 和 - 0.01 (0.03) p 值 0.62）和教育程度（- 0.03 (0.03) p 值 0.33 和 - 0.01 (0.02)，p 值 0.35) 证据变得微弱。我们没有发现肺功能下降或慢性阻塞性肺病导致认知功能下降的证据。以前的观察性研究可能受到残留混杂因素的影响。研究工作应侧重于肺功能和认知能力下降的共同风险因素，而不是仅将肺功能作为可改变的风险因素。在线版本包含可在 10.1186/s12890-021-01611-6 获取的补充材料。
Observational studies show an association between reduced lung function and impaired cognition. Cognitive dysfunction influences important health outcomes and is a precursor to dementia, but treatments options are currently very limited. Attention has therefore focused on identifying modifiable risk factors to prevent cognitive decline and preserve cognition. Our objective was to determine if lung function or risk of COPD causes reduced cognitive function using Mendelian randomization (MR). Single nucleotide polymorphisms from genome wide association studies of lung function and COPD were used as exposures. We examined their effect on general cognitive function in a sample of 132,452 individuals. We then performed multivariable MR (MVMR), examining the effect of lung function before and after conditioning for covariates. We found only weak evidence that reduced lung function (Beta − 0.002 (SE 0.02), p-value 0.86) or increased liability to COPD (− 0.008 (0.008), p-value 0.35) causes lower cognitive function. MVMR found both reduced FEV1 and FVC do cause lower cognitive function, but that after conditioning for height (− 0.03 (0.03), p-value 0.29 and − 0.01 (0.03) p-value 0.62, for FEV1 and FVC respectively) and educational attainment (− 0.03 (0.03) p-value 0.33 and − 0.01 (0.02), p-value 0.35) the evidence became weak. We did not find evidence that reduced lung function or COPD causes reduced cognitive function. Previous observational studies are probably affected by residual confounding. Research efforts should focus on shared risk factors for reduced lung function and cognition, rather than lung function alone as a modifiable risk factor. The online version contains supplementary material available at 10.1186/s12890-021-01611-6.
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DOI：
10.1042/cs20160043
发表时间：
2016-07-01
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Austin V;Crack PJ;Bozinovski S;Miller AA;Vlahos R
通讯作者：
Vlahos R
影响因子：
9.6
作者：
Liao, D;Higgins, M;Heiss, G
通讯作者：
Heiss, G
影响因子：
3.6
作者：
Bajaj, Mohani-Preet K.;Burrage, Daniel R.;Baker, Emma H.
通讯作者：
Baker, Emma H.
影响因子：
24.3
作者：
Higbee, Daniel H.;Granell, Raquel;Dodd, James W.
通讯作者：
Dodd, James W.
影响因子：
7.7
作者：
Burgess, Stephen;Thompson, Simon G.
通讯作者：
Thompson, Simon G.