Reproducibility of science: Fraud, impact factors and carelessness.
Reproducibility of science: Fraud, impact factors and carelessness.
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DOI：
10.1016/j.yjmcc.2017.10.009
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发表时间：
2018-01
影响因子：
5
通讯作者：
Eisner DA
中科院分区：
文献类型：
--
作者：
Eisner DA
人们非常担心，发表在很大一部分生物医学论文上的结果可能无法重现。本文回顾了这方面的证据，并考虑了一些负责的因素以及如何解决这一问题。其中一个问题是科学造假。反过来，这可能是因为科学家面临着成功的压力，包括需要在“高影响力”期刊上发表文章。我强调判断科学本身质量的重要性，而不是使用替代指标。讨论的其他因素包括实验设计和工作的统计分析问题。重要的是，在其他人实施严厉的规定之前，科学界必须解决这些问题。许多科学是不能复制的；这篇文章回顾了原因。欺诈，有时受到在高影响力期刊上发表文章的需要的鼓励，也起到了作用。另一个主要因素是糟糕的实验设计和统计分析。科学界需要在改变被强加之前进行改革。
There is great concern that results published in a large fraction of biomedical papers may not be reproducible. This article reviews the evidence for this and considers some of the factors that are responsible and how the problem may be solved. One issue is scientific fraud. This, in turn, may result from pressures put on scientists to succeed including the need to publish in “high impact” journals. I emphasise the importance of judging the quality of the science itself as opposed to using surrogate metrics. The other factors discussed include problems of experimental design and statistical analysis of the work. It is important that these issues are addressed by the scientific community before others impose draconian regulations. Much of science cannot be reproduced; this article reviews the causes. Fraud, sometimes encouraged by the need to publish in high impact journals contributes. Another, major factor, is poor experimental design and statistical analysis. The scientific community needs to reform before change is thrust upon it.
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影响因子：
14.8
作者：
Arrowsmith CH;Audia JE;Austin C;Baell J;Bennett J;Blagg J;Bountra C;Brennan PE;Brown PJ;Bunnage ME;Buser-Doepner C;Campbell RM;Carter AJ;Cohen P;Copeland RA;Cravatt B;Dahlin JL;Dhanak D;Edwards AM;Frederiksen M;Frye SV;Gray N;Grimshaw CE;Hepworth D;Howe T;Huber KV;Jin J;Knapp S;Kotz JD;Kruger RG;Lowe D;Mader MM;Marsden B;Mueller-Fahrnow A;Müller S;O'Hagan RC;Overington JP;Owen DR;Rosenberg SH;Roth B;Ross R;Schapira M;Schreiber SL;Shoichet B;Sundström M;Superti-Furga G;Taunton J;Toledo-Sherman L;Walpole C;Walters MA;Willson TM;Workman P;Young RN;Zuercher WJ
通讯作者：
Zuercher WJ
影响因子：
5.5
作者：
HODGKIN, AL;HUXLEY, AF
通讯作者：
HUXLEY, AF
影响因子：
15.8
作者：
Ioannidis, JPA
通讯作者：
Ioannidis, JPA
影响因子：
3.5
作者：
De Groote I;Flink LG;Abbas R;Bello SM;Burgia L;Buck LT;Dean C;Freyne A;Higham T;Jones CG;Kruszynski R;Lister A;Parfitt SA;Skinner MM;Shindler K;Stringer CB
通讯作者：
Stringer CB
影响因子：
3.5
作者：
Colquhoun D
通讯作者：
Colquhoun D