Changes in Serum Lipid Levels During Pregnancy and Association With Neonatal Outcomes: A Large Cohort Study
Changes in Serum Lipid Levels During Pregnancy and Association With Neonatal Outcomes: A Large Cohort Study
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怀孕期间血清脂质水平的变化及其与新生儿结局的关系：一项大型队列研究
DOI：
10.1177/1933719117746785
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Guanghui Li
中科院分区：
文献类型：
--
作者：
Wei Zheng;Wenyu Huang;Li Zhang;Zhihong Tian;Teng Wang;Ting Zhang;Zhi Zhang;Weiyuan Zhang;Guanghui Li
背景资料：本研究的目的是描述整个妊娠期间血脂水平的变化，并探讨血脂水平与新生儿结局之间的关系。研究方法：本研究纳入了2014年1月至2014年12月在北京妇产科医院接受常规产前护理并分娩的单胎妊娠女性。基线信息和新生儿结局从病历回顾中收集。测定妊娠早期（7-13周）和妊娠晚期（>32周）的血脂水平。建立多元回归模型来研究血脂水平和新生儿预后之间的关系。采用协方差结构分析探讨血脂谱对新生儿出生体重的影响。结果：共纳入10 366例孕妇。甘油三酯（TG）和总胆固醇水平显着增加，从第一个三个月到第三个三个月。妊娠早期和晚期的甘油三酯水平与巨大儿和早产的风险增加显著相关。孕早期血脂水平对孕晚期血脂水平有显著影响，而孕晚期TG和高密度脂蛋白胆固醇与出生体重相关。结论：妊娠期TG水平升高与早产和巨大儿风险增加相关。妊娠晚期的血脂水平主要由妊娠早期的血脂水平决定，也与出生体重有关。
Background: This study is aimed to characterize changes in serum lipid levels throughout pregnancy and explore the association between lipid levels and neonatal outcomes. Methods: This study included singleton pregnancy women who received regular prenatal care and delivered at Beijing Obstetrics and Gynecology Hospital from January 2014 to December 2014. Baseline information and neonatal outcomes were collected from medical record review. Serum lipid levels in the first trimester (7-13 weeks) and third trimester (>32 weeks) were measured. A multivariate regression model was constructed to examine the association between lipid levels and neonatal outcomes. Covariance structure analysis was conducted to explore the contribution of lipid profiles on birth weight. Results: A total of 10 366 pregnant women were included in the analysis. Triglyceride (TG) and total cholesterol levels increased significantly from the first trimester to the third trimester. Triglyceride levels in both early and late pregnancy were significantly associated with an increased risk of macrosomia and preterm birth. Serum lipid levels in the first trimester significantly contributed to the lipid levels in the third trimester, while TG and high-density lipoprotein cholesterol in the third trimester were associated with birth weight. Conclusion: Elevated TG levels throughout pregnancy were associated with an increased risk of preterm delivery and macrosomia. Serum lipid levels in the third trimester are mainly accounted for by their levels in the first trimester and are also associated with birth weight.
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影响因子：
3.3
作者：
Silveira, Patrícia P.;Portella, André K.;Barbieri, Marco A.
通讯作者：
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DOI：
10.1016/j.ijgo.2009.03.004
发表时间：
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3.5
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影响因子：
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通讯作者：
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