Maternal lipid change in relation to length of gestation: a prospective cohort study with preconception enrollment of women.
Maternal lipid change in relation to length of gestation: a prospective cohort study with preconception enrollment of women.
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DOI：
10.1159/000355100
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发表时间：
2014
影响因子：
2.1
通讯作者：
Buck Louis GM
中科院分区：
文献类型：
--
作者：
Laughon SK;McLain AC;Sundaram R;Catov JM;Buck Louis GM
我们试图调查孕前血脂和其每日变化率与妊娠时间的关系。在一组70名妇女中，61名（87%）怀孕，48名（69%）活产。血清脂质（mg/dL）测量包括在孕前、在hCG证实妊娠时和在妊娠丢失（< 14周）后或产后的总胆固醇、游离胆固醇、甘油三酯和磷脂。分别使用多项式回归和考克斯比例风险模型，校正体重指数和吸烟，对妊娠结局（流产、早产和足月分娩）和妊娠期长度相对于血脂每日变化率进行建模。与足月分娩相比，甘油三酯变化率低于中位数与妊娠丢失风险增加相关（校正OR 9.02，95% CI 1.62-50.30）。甘油三酯变化率低于≤ 0.01 mg/dL/天与高于中位数与妊娠丢失或早产（<37周）风险增加的趋势相关（校正HR 1.77，95% CI 0.94-3.33）。妊娠早期甘油三酯变化率低可能是妊娠丢失或早产风险的信号。血脂为识别有不良结局风险的妊娠提供了希望。
We sought to investigate the association between preconception serum lipids and their daily rate of change in relation to length of gestation. In a cohort of 70 women, 61 (87%) became pregnant resulting in 48 (69%) live births. Serum lipid (mg/dL) measurements included total cholesterol, free cholesterol, triglycerides, and phospholipids at preconception, upon hCG confirmed pregnancy and following pregnancy loss (< 14 weeks’) or postpartum. Pregnancy outcome (loss, preterm and term delivery) and gestational length were modeled relative to daily rate of change in lipids using multinomial regression and Cox proportional hazard models, respectively, adjusting for body mass index and smoking. Rate of triglyceride change below the median was associated with an increased risk for pregnancy loss compared to term birth (adjusted OR 9.02, 95% CI 1.62–50.30). Rate of triglyceride change below ≤ 0.01 mg/dL per day versus above the median was associated with a trend for increased risk of pregnancy loss or preterm (<37 weeks) birth (adjusted HR 1.77, 95% CI 0.94-3.33). A low rate of triglyceride change during early pregnancy may be a signal for risk of pregnancy loss or preterm birth. Lipids offer promise for identifying pregnancies at risk for adverse outcomes.
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影响因子：
4
作者：
PHILLIPS, DL;PIRKLE, JL;NEEDHAM, LL
通讯作者：
NEEDHAM, LL
DOI：
10.1016/0002-9378(79)90469-1
发表时间：
1979-01-01
影响因子：
9.8
作者：
POTTER, JM;NESTEL, PJ
通讯作者：
NESTEL, PJ
影响因子：
9.8
作者：
Catov, Janet M.;Bodnar, Lisa M.;Roberts, James M.
通讯作者：
Roberts, James M.
影响因子：
3.1
作者：
Joseph, K S
通讯作者：
Joseph, K S
影响因子：
5.8
作者：
Catov, Janet M.;Ness, Roberta B.;Gunderson, Erica P.
通讯作者：
Gunderson, Erica P.