Large-scale mortality gap between SLE and control population is associated with increased infection-related mortality in lupus.
Large-scale mortality gap between SLE and control population is associated with increased infection-related mortality in lupus.
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SLE和对照人群之间的大规模死亡率差距与狼疮中与感染相关的死亡率的增加有关。
DOI：
10.1093/rheumatology/keaa188
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发表时间：
2020-11-01
期刊：
影响因子：
--
通讯作者：
Nagy G
中科院分区：
文献类型：
--
作者：
Kedves M;Kósa F;Kunovszki P;Takács P;Szabó MZ;Karyekar C;Lofland JH;Nagy G
本研究的目的是在一项全人口、全国性的回顾性研究中，分析成年SLE患者和匹配的对照组的发病率、患病率、死亡率和死亡原因。这项非干预性研究基于匈牙利国家健康保险基金的数据库研究。共有7,888名患者被纳入分析，其中创建了两个亚组：所有事件系统性红斑狼疮患者组包括所有事件系统性红斑狼疮患者(4,503名患者)，而治疗系统性红斑狼疮患者组包括那些在确诊后前6个 月内接受相关治疗的患者(2,582名患者)。发现系统性红斑狼疮患者的年龄中位数为46.5 岁(女性占85%)。在“全部发病的SLE患者”和“治疗的SLE患者”组中，发病率分别为4.86/10万和2.78/10万居民。标准化死亡率分别为1.63和2.09。两组患者的总存活率均显著低于普通人群(P <； 0.001)，“所有发生的系统性红斑狼疮患者”组的风险比 = 为2.17，“经治疗的系统性红斑狼疮患者”组的风险比 = 为2.75。以脑血管疾病为死因的系统性红斑狼疮和对照死亡之间没有显著差异。一般来说，与癌症相关的死亡不太常见，而血液病和感染相关的死亡在SLE患者中更常见。感染，特别是败血症，对SLE的额外死亡率有最大的积极影响。这突显出SLE患者感染相关死亡的风险增加。
The aim of the present study was to analyse the incidence, prevalence, mortality and cause of death data of adult SLE patients and matched controls in a full-populational, nationwide, retrospective study. This non-interventional study was based on database research of the National Health Insurance Fund of Hungary. A total of 7888 patients were included in the analyses, within which two subgroups of incident patients were created: the ‘All incident SLE patients’ group consisted of all incident SLE patients (4503 patients), while the ‘Treated SLE patients’ group contained those who received relevant therapy in the first 6 months after diagnosis (2582 patients). The median age of the SLE population was found to be 46.5 years (women 85%). The incidence rate was 4.86 and 2.78 per 100 000 inhabitants in the ‘All incident SLE patients’ and ‘Treated SLE patients’ groups, respectively. The standardized mortality ratio was 1.63 and 2.09 in the ‘All incident SLE patients’ and ‘Treated SLE patients’ groups, respectively. Overall survival was significantly lower (P < 0.001) in both groups than in the general population, with hazard ratio = 2.17 in the ‘All incident SLE patients’ group and hazard ratio = 2.75 in the ‘Treated SLE patients’ group. There was no significant difference between SLE and control deaths regarding cerebrovascular conditions as the cause of death. Generally, cancer-related deaths were less common, while haematological cancer and infection-related deaths were more common in SLE patients. Infections, especially sepsis, had the largest positive effect on top of the extra mortality of SLE. This highlights that SLE patients are at increased risk of infection-related death.
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影响因子：
5.5
作者：
Jorge, April M.;Lu, Na;Choi, Hyon K.
通讯作者：
Choi, Hyon K.
DOI：
10.1016/0021-9681(55)90018-7
发表时间：
1955-01-01
期刊：
Journal of chronic diseases
影响因子：
--
作者：
MERRELL, M;SHULMAN, L E
通讯作者：
SHULMAN, L E
影响因子：
--
作者：
MCCARTY, DJ;MANZI, S;KWOH, CK
通讯作者：
KWOH, CK
影响因子：
--
作者：
Karlson, Elizabeth W.;Watts, Julie;Fraser, Patricia A.
通讯作者：
Fraser, Patricia A.
影响因子：
4.7
作者：
Flower, Cindy;Hennis, Anselm J. M.;Liang, Matthew H.
通讯作者：
Liang, Matthew H.