Interactions between bacterial endotoxin and other stimulators of bone resorption in organ culture.
Interactions between bacterial endotoxin and other stimulators of bone resorption in organ culture.
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器官培养中细菌内毒素与其他骨吸收刺激物之间的相互作用。
DOI：
10.1111/j.1600-0765.1981.tb00943.x
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发表时间：
1981
影响因子：
3.5
通讯作者：
Craig,RG
中科院分区：
文献类型：
--
作者：
Raisz,LG;Nuki,K;Alander,CB;Craig,RG
在牙槽骨丢失的发病机制中涉及的四种药物。在牙周病中，研究了内毒素、前列腺素E2（PGE2）、甲状旁腺激素（PTH）和破骨细胞激活因子（OAF）对骨吸收的影响，通过测量19日龄胎鼠长骨轴中先前合并的45ca的释放来测量。内毒素浓度为4 ~ 25 ng/ml时，45ca的释放量几乎没有增加，但能增强对PGE2、PTH和OAF亚最大浓度的反应。反应表现出协同效应，即单独添加药剂时的反应大于单个反应的总和。当PTH和pge2加在一起时，没有这种明显的协同作用。三种结构无关的前列腺素合成抑制剂吲哚美辛、氟芬那酸和RO 20-5720均不抑制内毒素的作用，在吲哚美辛存在的情况下，pge2和内毒素的协同效应相似。我们得出结论，内毒素和其他骨吸收剂之间的相互作用可以产生意想不到的大的骨吸收反应，并表明这些相互作用可能在牙周病和其他形式的病理性骨溶解的骨质流失的发病机制中很重要。
Four agents which have been implicated in the pathogenesis of alveolar bone loss. In periodontaI disease, endotoxin, prostagandin E2(PGE2), parathyroid hormone (PTH) and osteoclast activating factor (OAF), were studied for their effects on bone resorption as measured by the release of previously incorporated45Ca from long bone shafts of 19 day fetal rats. Endotoxin at concentrations of 4 to 25 ng/ml caused little increase in45Ca release but was able to enhance the response to submaximal concentrations of PGE2, PTH, and OAF. The response appeared synergistic, that is, it was greater than the sum of the individual responses when the agents were added singly. PTH and PGE2do not show such apparent synergism when added together. The effects of endotoxin were not inhibited by three structurally unrelated inhibitors of prostaglandin synthesis, indomethacin, flufenamic acid and RO 20–5720, and synergistic responses were similar when PGE2and endotoxin were added in the presence of indomethacin. We conclude that interactions between endotoxin and other bone resorbers can produce unexpectedly large resorptive responses and suggest that these interactions may be important in the pathogenesis of bone loss in periodontaJ disease and other forms of pathologic osteolysis.
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影响因子：
56.9
作者：
L. Raisz;A. Sandberg;J. M. Goodson;H. Simmons;S. E. Mergenhagen
通讯作者：
S. E. Mergenhagen
聚-L-赖氨酸增强甲状旁腺激素刺激的骨吸收。
影响因子：
4.8
作者：
L. Raisz;P. Bergmann;J. Dominguez;M. Price
通讯作者：
M. Price
结扎线中骨吸收活性的出现诱发了狗的牙龈炎。
影响因子：
3.5
作者：
W. Soskolne;K. Nuki;L. Raisz;C. Alander
通讯作者：
C. Alander
脂多糖和前列腺素对大鼠骨细胞钙和环AMP的影响。
影响因子：
3
作者：
R. Dziak;E. Hausmann;Y. W. Chang
通讯作者：
Y. W. Chang
影响因子：
4.3
作者：
NYMAN, S;SCHROEDER, HE;LINDHE, J
通讯作者：
LINDHE, J