Abnormalities in Cutaneous Microcirculation in Patients with Alzheimer's Disease, Mild Cognitive Impairment, and Chronic Insomnia Disorder.
Abnormalities in Cutaneous Microcirculation in Patients with Alzheimer's Disease, Mild Cognitive Impairment, and Chronic Insomnia Disorder.
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DOI：
10.3390/jcm10245718
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发表时间：
2021-12-07
影响因子：
3.9
通讯作者：
Yu HS
中科院分区：
文献类型：
--
作者：
Yu S;Hsu CY;Chuang HY;Yang CC;Lai CL;Yu HS
在神经退行性疾病，如阿尔茨海默病（AD）中经常观察到交感神经反应受损。另一方面，慢性失眠症（CID）也常伴有交感神经的激活。考虑到皮肤微循环反映交感神经紧张，我们假设激光多普勒血流仪（LDF）检测到的手指皮肤微循环基线在轻度认知障碍（MCI）、AD和CID患者中是不同的。由于光疗是AD和CID的辅助治疗之一，我们设计了一项为期12周的随机对照眼光疗交叉试验，以红光为治疗，绿光为对照肢体，观察光疗对皮肤微循环是否有影响。在光疗前，AD患者在左、右一至四指的基线皮肤灌注明显低于CID患者。而红光治疗后，CID患者手指皮肤灌注明显减少（右侧手指，术前vs后= 227.25±62.00 vs. 162.00±49.34,p = 0.007；左侧手指，术前vs.后= 228.99±58.80 vs. 177.41±59.41,p = 0.003），而绿光治疗后CID患者手指皮肤灌注无明显变化。红光光治疗也显著增加AD患者手指皮肤灌注（右指，治疗前后= 130.13±49.82 vs. 172.38±38.32,p = 0.043）。我们的研究结果表明，皮肤灌注是检测CID和AD患者交感功能障碍的有用工具，而红光光疗法是逆转CID和AD患者交感功能受损的潜在治疗干预措施。
Impaired sympathetic response is frequently observed in neurodegenerative diseases, such as Alzheimer’s disease (AD). On the other hand, chronic insomnia disorder (CID) is also often accompanied by activation of sympathetic nerves. Considering that cutaneous microcirculation reflects sympathetic tone, we hypothesized that baseline cutaneous microcirculation in fingers, as detected by laser Doppler flowmetry (LDF), differs among patients with mild cognitive impairment (MCI), AD, and CID. As light therapy is one of the adjunctive treatments for AD and CID, we designed a randomized controlled cross-over trial of light therapy through eyes for 12 weeks with red light as treatment and green light as control limb, and examined if light therapy has an impact on cutaneous microcirculation. Before light therapy, patients with AD had significantly lower baseline cutaneous perfusion than those with CID in left and right first to fourth fingers. After red light therapy, however, cutaneous perfusion of fingers in CID patients significantly decreased (right fingers, before vs. after = 227.25 ± 62.00 vs. 162.00 ± 49.34, p = 0.007; left fingers, before vs. after = 228.99 ± 58.80 vs. 177.41 ± 59.41, p = 0.003) while cutaneous perfusion of fingers in CID patients did not significantly change after green light therapy. Light therapy with red light also significantly increased cutaneous finger perfusion in patients with AD (right fingers, before vs. after = 130.13 ± 49.82 vs. 172.38 ± 38.32, p = 0.043). Our results suggest that cutaneous perfusion is a useful tool to detect sympathetic dysfunction in patients with CID and AD, and that light therapy with red light is a potential therapeutic intervention to reverse impaired sympathetic function in patients with CID and patients with AD.
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影响因子：
3.1
作者：
Bernjak, A.;Deitrick, G. A.;Tuckman, J.
通讯作者：
Tuckman, J.
DOI：
10.1073/pnas.1708361114
发表时间：
2017-07-11
影响因子：
11.1
作者：
Noseda, Rodrigo;Lee, Alice J.;Burstein, Rami
通讯作者：
Burstein, Rami
DOI：
10.1093/geronj/44.1.m8
发表时间：
1989-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
BORSON, S;BARNES, RF;RASKIND, MA
通讯作者：
RASKIND, MA
影响因子：
2.1
作者：
Liu, Ju-Chi;Hsu, Yi-Ping;Hsiu, Hsin
通讯作者：
Hsiu, Hsin
影响因子：
3.2
作者：
Perpetuini, David;Cardone, Daniela;Merla, Arcangelo
通讯作者：
Merla, Arcangelo