Population attributable fractions for risk factors and disability burden of dementia in Jiangxi Province, China: a cross-sectional study.
Population attributable fractions for risk factors and disability burden of dementia in Jiangxi Province, China: a cross-sectional study.
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DOI：
10.1186/s12877-022-03507-4
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发表时间：
2022-10-21
期刊：
影响因子：
4.1
通讯作者：
Hu, Songbo
中科院分区：
文献类型：
--
作者：
Wu, Yuhang;Zheng, Huilie;Xu, Fenfei;Guo, Jin;Liu, Zhitao;Wang, Shengwei;Chen, Xiaoyun;Cao, Yu;Zou, Wei;Hu, Songbo
鉴于痴呆症并无有效的治疗方法，痴呆症患者在其馀生中须与痴呆症共处的年数会逐渐增加，而痴呆症所引致的失能损失亦会增加。因此，研究危险因素对痴呆的影响，充分发挥预防的潜力，是一项迫切的工作。本研究的目的是通过评估江西省老年痴呆的人口归因分数（PAF）来量化由危险因素引起的痴呆残疾负担。9项危险因素的患病率数据是通过2018年第六次全国卫生服务调查获得的，该调查覆盖了2713名老年人。Levin公式被用来计算每个痴呆危险因素的PAF。我们根据危险因素之间的共同性调整了PAF，并使用这些值来计算总体加权PAF和残疾生活年数（YLD），这可归因于9个危险因素。理论上可以通过9种确定的危险因素预防的痴呆病例数和比例分别为111636（99595-120877）和66.8%（59.6- 72.3%）。痴呆的总YLD估计为61136（46463-78369）（男性：36434 [24100-49330]，女性：23956 [14716-34589]）。缺乏体力活动（11639 [8845-14920]）、社会接触少（9324 [7086-11952]）和听力损失（5668 [4307-7265]）是痴呆症的前三大因素。以江西省为代表的中度老龄化地区在痴呆预防方面具有很大的潜力。有针对性的干预措施和风险因素的管理可以有效降低痴呆的残疾负担。在线版本包含补充材料，可通过10.1186/s12877-022-03507-4获得。
In view of the fact that there is no effective treatment for dementia, the number of years that dementia patients have to live with dementia will gradually increase for the rest of their lives, and the disability loss caused by dementia will increase. It is urgent to study the influence of risk factors on dementia by making use of the potential of prevention. The purpose of this study is to quantify the burden of dementia disability attributable to risk factors by assessing the population attributable fractions (PAFs) in Jiangxi Province, which is one of the regions of moderate aging process of China. The prevalence data of nine risk factors were obtained through the Sixth National Health Service Survey in 2018, which covered 2713 older people. Levin’s formula was used to calculate the PAF for each risk factor for dementia. We adjusted the PAF for communality between risk factors, and used these values to calculate overall weighted PAFs and the years lived with disability (YLDs), which were attributable to nine risk factors. The number of dementia cases and their proportions that can theoretically be prevented by nine identified risk factors were 111636 (99595-120877) and 66.8% (59.6-72.3), respectively. The total YLDs of dementia were estimated to be 61136 (46463-78369) (males: 36434 [24100-49330], females: 23956 [14716-34589]). Physical inactivity (11639 [8845-14920]), low social contact (9324 [7086-11952]), and hearing loss (5668 [4307-7265] were the top three contributors to dementia. The moderate aging areas represented by Jiangxi Province have great potential in the prevention of dementia. Targeted interventions and management of risk factors can effectively reduce the disability burden of dementia. The online version contains supplementary material available at 10.1186/s12877-022-03507-4.
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DOI：
10.1097/mco.0b013e32831c8c71
发表时间：
2009-01
影响因子：
3.1
作者：
Luchsinger JA;Gustafson DR
通讯作者：
Gustafson DR
影响因子：
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DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
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作者：
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通讯作者：
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影响因子：
34.3
作者：
Mukadam, Naaheed;Sommerlad, Andrew;Livingston, Gill
通讯作者：
Livingston, Gill