Association between breath methane concentration and visceral fat area: a population-based cross-sectional study
Association between breath methane concentration and visceral fat area: a population-based cross-sectional study
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呼吸甲烷浓度与内脏脂肪面积之间的关联：基于人群的横断面研究
DOI：
10.1088/1752-7163/ab61c6
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发表时间：
2020
影响因子：
3.8
通讯作者：
Nakaji Shigeyuki
中科院分区：
文献类型：
--
作者：
Ozato Naoki;Saito Shinichiro;Yamaguchi Tohru;Katashima Mitsuhiro;Tokuda Itoyo;Sawada Kaori;Katsuragi Yoshihisa;Kakuta Masanori;Imoto Seiya;Ihara Kazushige;Nakaji Shigeyuki
与体重指数（BMI）和腰围（WC）相比，高内脏脂肪面积（VFA）是心血管疾病和总体死亡率的更强预测因子。最近的报告表明，肥胖与呼吸气体有关，呼吸气体由肠道微生物菌群产生。然而，这些研究使用BMI来定义肥胖，而不是VFA。在这项基于人群的横断面研究中，我们调查了呼吸气体（甲烷和氢气）与VFA和BMI之间的关系。2015年日本Iwaki健康促进项目共招募了1033名参与者（62%为女性;年龄[平均值±标准差] 54.4±14.9岁）。使用呼吸袋收集呼吸样本，并通过气相色谱法进行分析。使用内脏脂肪计测量VFA。通过聚合酶链反应和16 S rRNA基因测序分析来测量产甲烷细菌占总肠道微生物群的比例。我们的分析揭示了高VFA和低呼吸甲烷之间的显著关联，即使在调整了混杂因素之后（B=-0.024和P= 0.004）。为了确定呼吸甲烷和VFA之间的关联，参与者的肠道微生物菌群中有产甲烷细菌，参与者根据粪便中是否存在产甲烷细菌分为两组。甲烷菌+组进一步分为两个亚组，呼吸甲烷高于（甲烷-UP）或低于（甲烷-LO）中位呼吸甲烷浓度。甲烷-UP组的VFA显著低于甲烷-LO组。在产甲烷细菌的参与者中，呼吸甲烷浓度可能是内脏脂肪积累的独立生物标志物。
High visceral fat area (VFA) is a stronger predictor of cardiovascular disease and overall mortality, compared with body mass index (BMI) and waist circumference (WC). Recent reports demonstrate that obesity is related to breath gas, which is produced by the intestinal microflora. However, these studies define obesity using BMI, not VFA. In this population-based cross-sectional study, we investigated the relationship between breath gases (methane and hydrogen) and both VFA and BMI. A total of 1033 participants (62% women; age [mean±standard deviation] 54.4±14.9 years) in the 2015 Iwaki Health Promotion Project in Japan were enrolled in the study. Breath samples were collected using a breath bag and analyzed by gas chromatography. VFA was measured using a visceral fat meter. The proportion of methanogenic bacteria to total intestinal microbiota was measured by polymerase chain reaction and 16S rRNA gene sequencing analysis. Our analysis revealed a significant association between high VFA and low breath methane, even after adjusting for confounding factors (B=− 0.024 and P= 0.004). To identify the association between breath methane and VFA in participants with methane-producing bacteria in their intestinal microflora, participants were divided into two groups based on the presence or absence of methanogenic bacteria in their stool. The Methanogen+ group was further divided into two subgroups with breath methane higher (Methane-UP) or lower (Methane-LO) than the median breath methane concentration. VFA was significantly lower in the Methane-UP group than in the Methane-LO group. In participants with methanogenic bacteria, breath methane concentration might be an independent biomarker of visceral fat accumulation.
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