The role of SUMOylation in the neurovascular dysfunction after acquired brain injury.
The role of SUMOylation in the neurovascular dysfunction after acquired brain injury.
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SUMOylation在获得性脑损伤后神经血管功能障碍中的作用。
DOI：
10.3389/fphar.2023.1125662
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发表时间：
2023
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
后天性脑损伤是最常见的神经系统疾病，涉及复杂的病理过程，常导致一系列神经系统疾病。神经血管单元（NVU）的结构破坏和功能障碍是ABI的突出特征。因此，了解NVU破坏及其重建的分子机制是ABI治疗的关键。SUMOylation是一种蛋白质翻译后修饰（PTM），可以动态降解和稳定底物，在调节蛋白质表达和生物信号转导中发挥重要作用。了解SUMOylation的调控机制，可以阐明ABI后神经血管功能障碍发生发展的分子机制，有望为制定潜在的治疗策略提供理论依据。本文综述了SUMOylation在ABI相关血管事件中的作用，包括NVU功能障碍和血管重构，并提出了治疗前景。
Acquired brain injury (ABI) is the most common disease of the nervous system, involving complex pathological processes, which often leads to a series of nervous system disorders. The structural destruction and dysfunction of the Neurovascular Unit (NVU) are prominent features of ABI. Therefore, understanding the molecular mechanism underlying NVU destruction and its reconstruction is the key to the treatment of ABI. SUMOylation is a protein post-translational modification (PTM), which can degrade and stabilize the substrate dynamically, thus playing an important role in regulating protein expression and biological signal transduction. Understanding the regulatory mechanism of SUMOylation can clarify the molecular mechanism of the occurrence and development of neurovascular dysfunction after ABI and is expected to provide a theoretical basis for the development of potential treatment strategies. This article reviews the role of SUMOylation in vascular events related to ABI, including NVU dysfunction and vascular remodeling, and puts forward therapeutic prospects.
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