Landscape of immune cell infiltration in clear cell renal cell carcinoma to aid immunotherapy.
Landscape of immune cell infiltration in clear cell renal cell carcinoma to aid immunotherapy.
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DOI：
10.1111/cas.14887
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发表时间：
2021-06
期刊：
影响因子：
5.7
通讯作者：
Sugiyama H
中科院分区：
文献类型：
--
作者：
Bai D;Feng H;Yang J;Yin A;Qian A;Sugiyama H
由肿瘤细胞和肿瘤浸润免疫细胞组成的肿瘤微环境与肾透明细胞癌（ccRCC）患者的临床结局密切相关。然而，ccRCC中的免疫浸润景观尚未完全阐明。在此，我们应用多种计算方法和各种数据集来揭示ccRCC患者的免疫浸润景观。使用单样本基因检查了525例ccRCC患者的肿瘤免疫浸润（TII）水平，并进一步分类为免疫浸润亚组。TII评分的特点是不同的临床特征，并显示出显着的分歧，性别，年级和阶段。高TII评分与ERBB信号通路、TGF-β信号通路和MTOR信号通路以及更好的预后相关。此外，具有高TII评分的患者表现出对帕唑帕尼更高的敏感性。低TII评分的特征在于CD 8 + T细胞、T滤泡辅助细胞和调节性T细胞（TcB）的高免疫浸润水平。此外，包括CTLA-4、LAG 3、PD-1和IDO 1在内的免疫检查点基因在低TII评分组中呈现高表达水平。高TII评分组的患者表现出显著的治疗优势和临床获益。这项研究的发现有可能有助于ccRCC免疫治疗的战略设计。系统研究了525例肾透明细胞癌（ccRCC）患者的肿瘤免疫浸润（TII）水平，以及肿瘤浸润免疫细胞与临床结局之间的相关性。高TII评分与ERBB、TGF-β和MTOR信号通路相关。此外，TII评分高的患者对舒尼替尼、顺铂和长春碱的敏感性更高。包括CTLA-4、LAG 3、PD-1和IDO 1在内的免疫检查点基因在低TII评分组中呈现高表达水平。本研究证实，TII评分可以作为免疫治疗的有效预后生物标志物。
The tumor microenvironment, comprised of tumor cells and tumor‐infiltrating immune cells, is closely associated with the clinical outcome of clear cell renal cell carcinoma (ccRCC) patients. However, the landscape of immune infiltration in ccRCC has not been fully elucidated. Herein, we applied multiple computational methods and various datasets to reveal the immune infiltrative landscape of ccRCC patients. The tumor immune infiltration (TII) levels of 525 ccRCC patients using a single‐sample gene were examined and further categorized into immune infiltration subgroups. The TII score was characterized by distinct clinical traits and showed a significant divergence based on gender, grade, and stage. A high TII score was associated with the ERBB signaling pathway, the TGF‐β signaling pathway, and the MTOR signaling pathway, as well as a better prognosis. Furthermore, patients with high TII scores exhibited greater sensitivity to pazopanib. The low TII score was characterized by a high immune infiltration level of CD8+ T cells, T follicular helper cells, and regulatory T cells (Tregs). Moreover, the immune check point genes, including CTLA‐4, LAG3, PD‐1, and IDO1, presented a high expression level in the low TII score group. Patients in the high TII score group demonstrated significant therapeutic advantages and clinical benefits. The findings in this study have the potential to assist in the strategic design of immunotherapeutic treatments for ccRCC. The tumor immune infiltration (TII) level of 525 clear cell renal cell carcinoma (ccRCC) patients was systematically investigated, as well as the association between tumor‐infiltrating immune cells and clinical outcomes. The high TII score was associated with the ERBB, the TGF‐β, and the MTOR signaling pathway. Furthermore, patients with high TII scores exhibited greater sensitivity to sunitinib, cisplatin, and vinblastine. The immune check point genes, including CTLA‐4, LAG3, PD‐1, and IDO1, presented high expression levels in the low TII score group. The present study confirmed that TII scores can serve as effective prognostic biomarkers for immunotherapy.
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影响因子：
14.9
作者：
Ritchie ME;Phipson B;Wu D;Hu Y;Law CW;Shi W;Smyth GK
通讯作者：
Smyth GK
基于透明细胞肾细胞癌中表达的免疫相关基因的临床预后模型的开发和验证
影响因子：
4.7
作者：
Ren, Shiqi;Wang, Wei;Wang, Ziheng
通讯作者：
Wang, Ziheng
DOI：
10.1016/j.omtn.2020.08.030
发表时间：
2020-12-04
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
Zhang X;Shi M;Chen T;Zhang B
通讯作者：
Zhang B
DOI：
10.1038/nri3862
发表时间：
2015-08
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Wherry EJ;Kurachi M
通讯作者：
Kurachi M
影响因子：
4.5
作者：
Antonelli, Alessandro;Cozzoli, Alberto;Simeone, Claudio
通讯作者：
Simeone, Claudio