Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans.
Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans.
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DOI：
10.1186/1742-4933-10-3
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发表时间：
2013-01-23
期刊：
影响因子：
--
通讯作者：
Gollapudi S
中科院分区：
文献类型：
--
作者：
Gupta S;Agrawal S;Gollapudi S
衰老与慢性炎症和自身免疫以及瘦素水平升高有关。瘦素水平升高与炎症和自身免疫有关。我们最近报道瘦素激活 B 细胞诱导促炎和抗炎细胞因子的分泌。 B 细胞和瘦素在与衰老相关的炎症中的作用尚未被探索。在这项研究中，我们证明，与年轻对照组相比，瘦素可激活并诱导老年人 B 细胞产生显着更多量的 IL-6、TNF-α 和 IL-10。与年轻受试者相比，这与老年人 B 细胞中瘦素诱导的 STAT3（信号转导子和转录激活子 3）磷酸化增加有关。这些数据表明，瘦素诱导的 B 细胞衍生的促炎细胞因子可能在与人类衰老相关的慢性炎症中发挥作用。
Aging is associated chronic inflammation and autoimmunity, and increased levels of leptin. Increased levels of leptin are associated with inflammation and autoimmunity. We have recently reported that leptin activates B cells to induce secretion of proinflammatory and anti-inflammatory cytokines. Role of B cells and leptin in inflammation associated with aging has not been explored. In this study we demonstrate that leptin activates and induces significantly greater amount of IL-6, TNF-α, and IL-10 by B cells from aged humans as compared to young controls. This is associated with increased leptin-induced phosphorylation of STAT3 (signal transducer and activator of transcription-3) in B cells from aged humans as compared to young subjects. These data suggest that leptin-induced B cell-derived proinflammatory cytokines may play a role in chronic inflammation associated with human aging.
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影响因子：
9.1
作者：
Agrawal, Sudhanshu;Gupta, Sudhir
通讯作者：
Gupta, Sudhir
影响因子：
5.3
作者：
Forsey, RJ;Thompson, JM;Wikby, A
通讯作者：
Wikby, A
影响因子：
32.4
作者：
De Rosa, Veronica;Procaccini, Claudio;Matarese, Giuseppe
通讯作者：
Matarese, Giuseppe
影响因子：
5.5
作者：
Chelvarajan, RL;Collins, SM;Bondada, S
通讯作者：
Bondada, S
影响因子：
--
作者：
Buffa, Silvio;Pellicano, Mariavaleria;Colonna-Romano, Giuseppina
通讯作者：
Colonna-Romano, Giuseppina