Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field.
Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field.
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DOI：
10.1111/j.1461-0248.2012.01791.x
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发表时间：
2012-07
期刊：
影响因子：
8.8
通讯作者：
Milinski M
中科院分区：
文献类型：
--
作者：
Eizaguirre C;Lenz TL;Kalbe M;Milinski M
虽然对于理解适应性进化至关重要，但遗传上解决局部适应的例子很少。为了在当地环境中最大限度地生存和繁殖，宿主应该抵抗当地的寄生虫和病原体。主要组织相容性复合体（MHC）是研究寄生虫介导的局部适应的理想分子。使用复制的现场围隔，与第二代实验室饲养的三棘鱼杂交的湖泊和河流的人口，我们表现出当地的适应MHC基因型的人口特异性寄生虫，独立的遗传背景。湖泊MHC基因型的等位基因分歧增加，使湖泊鱼类打击广泛的湖泊寄生虫，而更具体的河流基因型赋予选择性优势，对不同的河流寄生虫。与当地的MHC基因型的杂交获得更多的体重，从而更高的健身比那些与外国MHC在任何栖息地，这表明当地适应的MHC基因型的进化意义。
Although crucial for the understanding of adaptive evolution, genetically resolved examples of local adaptation are rare. To maximize survival and reproduction in their local environment, hosts should resist their local parasites and pathogens. The major histocompatibility complex (MHC) with its key function in parasite resistance represents an ideal candidate to investigate parasite-mediated local adaptation. Using replicated field mesocosms, stocked with second-generation lab-bred three-spined stickleback hybrids of a lake and a river population, we show local adaptation of MHC genotypes to population-specific parasites, independently of the genetic background. Increased allele divergence of lake MHC genotypes allows lake fish to fight the broad range of lake parasites, whereas more specific river genotypes confer selective advantages against the less diverse river parasites. Hybrids with local MHC genotype gained more body weight and thus higher fitness than those with foreign MHC in either habitat, suggesting the evolutionary significance of locally adapted MHC genotypes.
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影响因子：
56.9
作者：
Barrett, Rowan D. H.;Rogers, Sean M.;Schluter, Dolph
通讯作者：
Schluter, Dolph
影响因子：
4.9
作者：
Ekblom, Robert;Saether, Stein Are;Hoglund, Jacob
通讯作者：
Hoglund, Jacob
DOI：
10.1098/rspb.2008.1466
发表时间：
2009-03-07
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Kalbe M;Eizaguirre C;Dankert I;Reusch TB;Sommerfeld RD;Wegner KM;Milinski M
通讯作者：
Milinski M
影响因子：
4.8
作者：
BERRYMAN, AA
通讯作者：
BERRYMAN, AA
影响因子：
3.3
作者：
Berner, Daniel;Grandchamp, Anne-Catherine;Hendry, Andrew P.
通讯作者：
Hendry, Andrew P.