Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity.
Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity.
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DOI：
10.1098/rspb.2008.1466
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发表时间：
2009-03-07
期刊：
影响因子：
--
通讯作者：
Milinski M
中科院分区：
文献类型：
--
作者：
Kalbe M;Eizaguirre C;Dankert I;Reusch TB;Sommerfeld RD;Wegner KM;Milinski M
在主要组织相容性复合体（MHC）的个体多样性预测是最佳的中间，而不是在最大水平。我们以前在刺鱼中发现，中间MHC多样性在自然种群中占主导地位，并在实验室中的实验性多种寄生虫感染中提供最大的抵抗力。然而，最终重要的是终身生殖成功（LRS）。在这里，我们测量了LRS的六个实验室饲养的兄弟组，以尽量减少非MHC基因的影响，三棘鱼（Gasterosteus aculeatus）在他们的整个繁殖期，每个在一个自然的外壳在湖上的父母，在那里他们暴露于自然的寄生虫谱。我们定期收集发育中的窝卵，并用18个微卫星确定每窝卵的代表性数量（共2279个）的亲子关系。具有中等MHC IIB类变体数量的男性和女性都具有最高的LRS。MHC多样性和LRS的机械链接不同的性别之间：在女性中，我们发现的证据之间的权衡的鸡蛋和immunocompentence的数量，而在男性中，这种相关性被掩盖了不同的时间策略的繁殖。
Individual diversity at the major histocompatibility complex (MHC) is predicted to be optimal at intermediate rather than at maximal levels. We showed previously in sticklebacks that an intermediate MHC diversity is predominant in natural populations and provides maximal resistance in experimental multiple parasite infections in the laboratory. However, what counts ultimately is the lifetime reproductive success (LRS). Here, we measured LRS of six laboratory-bred sib-groups—to minimize the influence of non-MHC genes—three-spined sticklebacks (Gasterosteus aculeatus) during their entire breeding period, each in a seminatural enclosure in the lake of their parents, where they were exposed to the natural spectrum of parasites. We collected developing clutches at regular intervals and determined parenthood for a representative number of eggs (2279 in total) per clutch with 18 microsatellites. Both males and females with an intermediate MHC class IIB variant number had the highest LRS. The mechanistic link of MHC diversity and LRS differed between the sexes: in females, we found evidence for a trade-off between number of eggs and immunocompentence, whereas in males this correlation was concealed by different timing strategies of reproduction.
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影响因子：
1.9
作者：
FRISCHKNECHT, M
通讯作者：
FRISCHKNECHT, M
影响因子：
3.2
作者：
Bonneaud, C;Richard, M;Sorci, G
通讯作者：
Sorci, G
影响因子：
56.9
作者：
BRILES, WE;BRILES, RW;STONE, HA
通讯作者：
STONE, HA
影响因子：
168.9
作者：
DOHERTY, PC;ZINKERNAGEL, RM
通讯作者：
ZINKERNAGEL, RM
DOI：
10.1098/rspb.2002.2036
发表时间：
2002-07-07
影响因子：
4.7
作者：
Brown, CR;Brown, MB
通讯作者：
Brown, MB