A magnetic resonance imaging grading system for subarachnoid hemorrhage severity in a rat model.
A magnetic resonance imaging grading system for subarachnoid hemorrhage severity in a rat model.
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DOI：
10.1016/j.jneumeth.2015.01.035
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发表时间：
2015-03-30
影响因子：
3
通讯作者：
Xi, Guohua
中科院分区：
文献类型：
--
作者：
Shishido, Hajime;Egashira, Yusuke;Okubo, Shuichi;Zhang, Haining;Hua, Ya;Keep, Richard F.;Xi, Guohua
蛛网膜下腔出血（SAH）的血管内穿孔模型在结果上有很大的差异。这可能反映了SAH大小的差异。对成年雄性（n = 58）和雌性（n = 58）大鼠血管穿孔后24小时进行磁共振成像（MRI）检查。根据MRI特征将大鼠分为5级：0级：无SAH或脑室内出血（IVH）；1级：轻度或轻度SAH，无IVH；2级：轻度或轻度SAH伴IVH；3级：厚SAH，无IVH；4级：厚SAH伴IVH。我们研究了MRI分级量表是否反映SAH的严重程度（死后确定）和神经学评分。雄性大鼠MRI分级量表与现行SAH分级量表（P < 0.01）和神经学评分（P < 0.01）有较强的相关性。在雌性大鼠中，MRI分级与SAH分级也有较强的相关性（P < 0.01），但与神经学评分无相关性（P = 0.24）。目前的分级制度是基于SAH的数量，需要动物安乐死来评估SAH的严重程度。没有有效的分级系统对SAH的严重程度进行分类而不将动物斩首。在血管内穿孔大鼠模型中，我们证明了MRI分级量表与当前SAH分级量表之间的相关性。MRI分级量表允许评估SAH的严重程度，而无需对动物实施安乐死。
The endovascular perforation model of subarachnoid hemorrhage (SAH) has a large variation in outcomes. This may reflect differences in the SAH size. Magnetic resonance imaging (MRI) was performed 24 hours after endovascular perforation in adult male (n = 58) and female (n = 58) rats. Rats were divided into five grades according to MRI characteristics: grade 0: no SAH or intraventricular hemorrhage (IVH); grade 1: minimal or thin SAH without IVH; grade 2: minimal or thin SAH with IVH; grade 3: thick SAH without IVH; grade 4: thick SAH with IVH. We investigated whether MRI grading scale reflected severity of SAH (determined post mortem) and neurological score. There was a strong correlation between MRI grading scale and current SAH grading scale (P < 0.01) and neurological score (P < 0.01) in male rats. In female rats, there was also a strong correlation between MRI grading scale and SAH grading scale (P < 0.01) but not with neurological score (P = 0.24). The current grading system is based on the amount of SAH and needs animal euthanasia to evaluate SAH severity. There is no useful grading system to classify severity of SAH without decapitating animals. We demonstrated a correlation between the MRI grading scale and the current SAH grading scale in an endovascular perforation rat model. The MRI grading scale allows evaluation of SAH severity without euthanizing animals.
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DOI：
10.1038/jcbfm.2010.137
发表时间：
2010-11
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.3
作者：
GARCIA, JH;WAGNER, S;HU, XJ
通讯作者：
HU, XJ
影响因子：
8.3
作者：
Park, S;Yamaguchi, M;Zhang, JH
通讯作者：
Zhang, JH
影响因子：
2.5
作者：
Yan, Feng;Hu, Qiang;Chen, Gao
通讯作者：
Chen, Gao
影响因子：
2.4
作者：
Jeon H;Ai J;Sabri M;Tariq A;Shang X;Chen G;Macdonald RL
通讯作者：
Macdonald RL