Apolipoprotein A-IV amyloidosis in a cotton-top tamarin (<i>Saguinus oedipus</i>)
Apolipoprotein A-IV amyloidosis in a cotton-top tamarin (<i>Saguinus oedipus</i>)
复制标题
棉顶狨猴 (<i>Saguinus oedipus</i>) 中的载脂蛋白 A-IV 淀粉样变性
DOI：
10.1080/13506129.2023.2169603
复制
发表时间：
2023
期刊：
影响因子：
5.5
通讯作者：
Murakami Tomoaki
中科院分区：
文献类型：
--
作者：
Sedghi Masoud Niki;Iwaide Susumu;Itoh Yoshiyuki;Hisada Miki;Une Yumi;Murakami Tomoaki
载脂蛋白a - iv （ApoAIV）淀粉样变性是一种罕见的系统性淀粉样变性，其特征是ApoAIV衍生的淀粉样沉积在肾脏和心脏[1,2]。迄今为止，ApoAIV淀粉样变性仅在人类中有报道，而在动物中没有报道。在这项研究中，我们对1例棉顶绢毛猴（Saguinus oedipus）系统性淀粉样变性进行了基于质谱的蛋白质组学分析，发现ApoAIV淀粉样变性具有不同于人类的独特病理特征。一只死于日本动物园的17岁雌性棉顶绢毛猴被用于研究。她有肺水肿、体温过低、腹泻和乏力的病史。组织学上，肾皮质间质和肾小球的淀粉样蛋白沉积严重，但髓质的淀粉样蛋白沉积较轻（图1 (ac)）。在肠固有层（图1 (df)）和肝脏间隙（补充图1 (mo)）也观察到严重的淀粉样蛋白沉积。在脾脏（图1 (gi)），
Apolipoprotein A-IV (ApoAIV) amyloidosis is a rare type of systemic amyloidosis characterised by ApoAIV-derived amyloid deposits in the kidney and heart [1, 2]. To date, ApoAIV amyloidosis has been reported only in humans and not in animals. In this study, we performed a mass spectrometry-based proteomic analysis on a case of systemic amyloidosis in cotton-top tamarin (Saguinus oedipus) and identified ApoAIV amyloidosis with unique pathological characteristics that differ from humans.A 17-year-old female cotton-top tamarin who died in the Japanese zoo was used for the research. She had a medical history of pulmonary edema, hypothermia, diarrhoea, and loss of energy. Histologically, amyloid deposits in kidneys were severe in the cortical interstitium and glomeruli, but mild in the medulla (Figure 1 (ac)). Severe amyloid deposition was also observed in lamina propria of the intestine (Figure 1 (df)) and in the space of Disse in the liver (Supplementary Figure 1 (mo)). In the spleen (Figure 1 (gi)),
蛋白质组分析证实全身性载脂蛋白 A-IV 相关淀粉样变性
影响因子：
3.5
作者：
Murakami Taro;Takasawa Akira;Moriki Asako;Igaki Yusuke;Ikeda Hiroshi;Murase Kazuyuki;Takada Kohichi;Magara Kazufumi;Aoyama Tomoyuki;Ono Yusuke;Kyuno Daisuke;Takasawa Kumi;Murata Masaki;Osanai Makoto
通讯作者：
Osanai Makoto
通过基于质谱的蛋白质组学分析诊断与载脂蛋白 A-IV 沉积相关的心脏淀粉样变性
影响因子：
--
作者：
Elisabete Martins;J. Urbano;S. Leite;Adriana Pinto;Raquel Garcia;Rui Bergantim;P. Rodrigues;P. Costa;Hugo Osório;I. Tavares
通讯作者：
I. Tavares
影响因子：
19.6
作者：
Dasari, Surendra;Amin, Md. Shahrier;Sethi, Sanjeev
通讯作者：
Sethi, Sanjeev