Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas.
Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas.
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DOI：
10.1016/j.neo.2017.09.002
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Carter CA
中科院分区：
文献类型：
--
作者：
Oronsky B;Ma PC;Morgensztern D;Carter CA
本综述涵盖了神经内分泌肿瘤（NENs）的不同主题，这是一种相对罕见且异质性的肿瘤类型，约占所有恶性肿瘤的2%，在美国的患病率<20万，这使其成为孤儿病（Basu et al., 2010）。从功能上看，NENs根据临床行为、组织学和增殖率分为两组：高分化（低级别到中级）神经内分泌肿瘤和低分化（高级别）神经内分泌癌（Bosman et al., 2010）；这种组织学分类/二分法对治疗和预后的影响具有高度临床相关性，尽管它不是绝对的，因为低级别外观的肿瘤子集的行为与高级别病变相似。考虑到关于这种孤儿疾病整体的循证文献相对缺乏（Modlin等人，2008年），3由于大多数文章的重点是NENs的特定解剖亚型（即胃肠胰或肺），本综述的目的是总结其表现、病理生理学、分期、当前的护理治疗标准和当前研究的活跃领域。
This review covers the diverse topic of neuroendocrine neoplasms (NENs), a relatively rare and heterogeneous tumor type, comprising ~2% of all malignancies, with a prevalence of <200,000 in the United States, which makes it an orphan disease (Basu et al., 2010). For functional purposes, NENs are divided into two groups on the basis of clinical behavior, histology, and proliferation rate: well differentiated (low grade to intermediate grade) neuroendocrine tumors and poorly differentiated (high grade) neuroendocrine carcinoma (Bosman et al., 2010); this histological categorization/dichotomization is highly clinically relevant with respect to impact on treatment and prognosis even though it is not absolute since a subset of tumors with a low-grade appearance behaves similarly to high-grade lesions. Given the relative dearth of evidenced-based literature about this orphan disease as a whole (Modlin et al., 2008),3 since the focus of most articles is on particular anatomic subtypes of NENs (i.e., gastroenteropancreatic or pulmonary), the purpose of this review is to summarize the presentation, pathophysiology, staging, current standard of care treatments, and active areas of current research.
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