Relationship between the discriminative stimulus properties and subjective effects of drugs.
Relationship between the discriminative stimulus properties and subjective effects of drugs.
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药物的辨别刺激特性与主观效果之间的关系。
DOI：
10.1007/978-3-642-73223-2_13
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Johanson,CE
中科院分区：
文献类型：
--
作者：
Schuster,CR;Johanson,CE
行为药理学家认为，药物介导其区别性刺激效应的性质与药物作用的各个方面有关，这些方面导致了药物在人类中的主观效应。这一假设的基础将在本章中加以探讨。支持这一假设的证据包括获得这两种行为所涉及的学习过程的形式属性。虽然用于训练动物学习药物辨别的程序是明确的，但对人类如何学习将言语反应与不可观察的内部主观状态联系起来的分析似乎涉及类似的学习范式。这两种效应的共同性的其他证据是，动物药物辨别研究和评估人类主观效应的研究得出了类似的药物分类。然而，当更详细地分析主观药物效应时，很明显，这两种方法之间的一致性并不总是很好。另一方面，当在人类中测量药物辨别和主观效应时，当个体对相同药物的反应不同时产生的结果的检查表明，他们的辨别是基于主观效应的特征的假设得到了支持。
Behavioral pharmacologists have assumed that the properties of drugs that mediate their discriminative stimulus effects are related to aspects of drug actions that result in their subjective effects in humans. The basis of this assumption is examined in this chapter. Evidence to support this assumption includes the formal properties of the learning process involved in acquiring both behaviors. Although the procedures used to train animals to learn a drug discrimination are explicit, an analysis of how humans learn to attach verbal responses to unobservable internal subjective states appears to involve a similar learning paradigm. Additional evidence of the commonality of the two effects is that the results from drug discrimination studies in animals and studies evaluating subjective effects in humans yield similar drug classifications. However, when subjective drug effects are analyzed in more detail, it is clear that the concordance between the two approaches is not always good. On the other hand, when drug discrimination and subjective effects are both measured in humans, an examination of the results generated when individuals respond differently to the same drug indicates that the hypothesis that their discrimination is based upon a profile of subjective effects is supported.
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DOI：
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