The changing microbial landscape of Western society: Diet, dwellings and discordance.
The changing microbial landscape of Western society: Diet, dwellings and discordance.
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DOI：
10.1016/j.molmet.2016.07.007
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发表时间：
2016-09
影响因子：
8.1
通讯作者：
Devkota S
中科院分区：
文献类型：
--
作者：
Broussard JL;Devkota S
过去50-100年的特点是，在那些经历了重大工业进步和向城市化生活转变的国家，所谓的“西方疾病”急剧上升。这些疾病包括肥胖、2型糖尿病、炎症性肠病和食物过敏，这些疾病似乎与代谢和/或免疫过程的慢性失调有关，很可能是新环境对我们古老基因组影响的副产品。我们现在所认识到的是，这个基因组由人类和共同进化的微生物基因组成，这些微生物是居住在我们体内的数万亿微生物。总之，宿主-微生物的相互作用可能是由西方生活方式的饮食和行为变化决定的，影响了“新时代”疾病的发病机制。这篇综述采用人类学的方法来研究宿主及其肠道微生物群在后工业化时期慢性炎症和代谢性疾病发病率上升中的潜在相互作用。讨论强调了与这些疾病同时发生的饮食和物理环境的变化，以及证明宿主-微生物相互作用在理解对环境变化的生物反应中的作用的最新证据。技术进步导致了农业和工程的变化，以人类历史上前所未有的方式改变了我们的饮食和生活行为。这些变化也改变了人体内的细菌群落，似乎与许多肠道和全身代谢和炎症性疾病的增加有关。对环境和人类肠道微生物群之间这种相互交换机制的深入了解，可能会为减轻影响生活质量的慢性健康状况提供潜力。这篇文章是关于微生物群的特刊的一部分。
The last 50–100 years has been marked by a sharp rise in so-called “Western-diseases” in those countries that have experienced major industrial advances and shifts towards urbanized living. These diseases include obesity, type 2 diabetes, inflammatory bowel diseases, and food allergies in which chronic dysregulation of metabolic and/or immune processes appear to be involved, and are likely a byproduct of new environmental influences on our ancient genome. What we now appreciate is that this genome consists of both human and co-evolved microbial genes of the trillions of microbes residing in our body. Together, host–microbe interactions may be determined by the changing diets and behaviors of the Western lifestyle, influencing the etiopathogenesis of “new-age” diseases. This review takes an anthropological approach to the potential interplay of the host and its gut microbiome in the post-industrialization rise in chronic inflammatory and metabolic diseases. The discussion highlights both the changes in diet and the physical environment that have co-occurred with these diseases and the latest evidence demonstrating the role of host–microbe interactions in understanding biological responses to the changing environment. Technological advances that have led to changes in agriculture and engineering have altered our eating and living behaviors in ways never before possible in human history. These changes also have altered the bacterial communities within the human body in ways that are seemingly linked with the rise of many intestinal and systemic metabolic and inflammatory diseases. Insights into the mechanisms of this reciprocal exchange between the environment and the human gut microbiome may offer potential to attenuate the chronic health conditions that derail quality of life. This article is part of a special issue on microbiota.
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影响因子：
30.3
作者：
Leone V;Gibbons SM;Martinez K;Hutchison AL;Huang EY;Cham CM;Pierre JF;Heneghan AF;Nadimpalli A;Hubert N;Zale E;Wang Y;Huang Y;Theriault B;Dinner AR;Musch MW;Kudsk KA;Prendergast BJ;Gilbert JA;Chang EB
通讯作者：
Chang EB
人脂肪外植体中时钟基因的昼夜节律。
影响因子：
6.9
作者：
Gomez-Santos, Cecilia;Gomez-Abellan, Purificacion;Madrid, Juan A.;Hernandez-Morante, Juan J.;Lujan, Juan A.;Ordovas, Jose M.;Garaulet, Marta
通讯作者：
Garaulet, Marta
影响因子：
29
作者：
Donohoe DR;Garge N;Zhang X;Sun W;O'Connell TM;Bunger MK;Bultman SJ
通讯作者：
Bultman SJ
DOI：
10.1073/pnas.1216951110
发表时间：
2013-04-02
影响因子：
11.1
作者：
Markwald, Rachel R.;Melanson, Edward L.;Wright, Kenneth P., Jr.
通讯作者：
Wright, Kenneth P., Jr.
影响因子：
4.9
作者：
Hanauer, SB
通讯作者：
Hanauer, SB