An open database of resting-state fMRI in awake rats.

An open database of resting-state fMRI in awake rats.
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DOI:
10.1016/j.neuroimage.2020.117094
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发表时间:
2020-10-15
期刊:
影响因子:
5.7
通讯作者:
Zhang N
Zhang N
中科院分区:
医学1区
文献类型:
--
作者:
Liu Y;Perez PD;Ma Z;Ma Z;Dopfel D;Cramer S;Tu W;Zhang N

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啮齿动物模型是健康和疾病转化研究的基础。利用静息态功能磁共振成像(rsfMRI)在系统水平上研究啮齿动物脑功能和组织已变得越来越流行。由于这一快速进展,公开共享的啮齿动物rsfMRI数据库可能对科学界特别感兴趣和重要,这是受到开放的人类神经成像数据集极大促进的人类神经科学和精神病学研究的启发。然而,在大鼠中的这种数据库仍然是罕见的。在本文中,我们分享了一个开放的rsfMRI数据库,在90只大鼠中获得了一个良好的清醒成像范例,避免麻醉干扰。原始数据和预处理数据都公开提供。详细描述了数据预处理过程,以去除由扫描仪、头部运动和非神经生理噪声引起的伪影。我们还展示了从数据库中获得的区域间功能连接和功能网络。
Rodent models are essential to translational research in health and disease. Investigation in rodent brain function and organization at the systems level using resting-state functional magnetic resonance imaging (rsfMRI) has become increasingly popular. Due to this rapid progress, publicly shared rodent rsfMRI databases can be of particular interest and importance to the scientific community, as inspired by human neuroscience and psychiatric research that are substantially facilitated by open human neuroimaging datasets. However, such databases in rats are still rare. In this paper, we share an open rsfMRI database acquired in 90 rats with a well-established awake imaging paradigm that avoids anesthesia interference. Both raw and preprocessed data are made publicly available. Procedures in data preprocessing to remove artefacts induced by the scanner, head motion and non-neural physiological noise are described in details. We also showcase inter-regional functional connectivity and functional networks obtained from the database.
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