Impact of intranasal oxytocin on interoceptive accuracy in alcohol users: an attentional mechanism?
Impact of intranasal oxytocin on interoceptive accuracy in alcohol users: an attentional mechanism?
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DOI：
10.1093/scan/nsy027
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发表时间：
2018-04-01
影响因子：
4.2
通讯作者：
Critchley H
中科院分区：
文献类型：
--
作者：
Betka S;Gould Van Praag C;Paloyelis Y;Bond R;Pfeifer G;Sequeira H;Duka T;Critchley H
内感受，即对内部身体信号的感知和评估，与渴望现象有关，据报道，内感受在酒精使用障碍中受到干扰。催产素激素影响身体信号的传入传递，并通过其对渴望的潜在调节，被提议作为酒精使用障碍的可能治疗方法。然而，催产素对饮酒者内感受的影响仍然未知。健康饮酒者（n = 32）在鼻内施用催产素或安慰剂后参加了两次实验室会议，以进行内感受能力测试（心跳追踪：关注内部信号和心跳辨别：整合内部和外部信号）。使用混合效应模型测试了内感受准确性、催产素施用和酒精摄入的影响。在跟踪任务中，催产素降低了内感受准确性，但与饮酒没有相互作用。在辨别任务中，我们发现催产素给药和酒精摄入之间存在相互作用：与安慰剂相比，催产素提高了重度饮酒者的内感受准确性，但对于轻度社交饮酒者却没有。我们的研究并不表明饮酒者存在纯粹的内感受障碍，而是可能强调内部和外部注意力资源分配的灵活性降低。重要的是，催产素似乎可以减轻这种损害。这种注意力假设需要在未来的研究中得到明确的检验。
Interoception, i.e. the perception and appraisal of internal bodily signals, is related to the phenomenon of craving, and is reportedly disrupted in alcohol use disorders. The hormone oxytocin influences afferent transmission of bodily signals and, through its potential modulation of craving, is proposed as a possible treatment for alcohol use disorders. However, oxytocin’s impact on interoception in alcohol users remains unknown. Healthy alcohol users (n = 32) attended two laboratory sessions to perform tests of interoceptive ability (heartbeat tracking: attending to internal signals and, heartbeat discrimination: integrating internal and external signals) after intranasal administration of oxytocin or placebo. Effects of interoceptive accuracy, oxytocin administration and alcohol intake, were tested using mixed-effects models. On the tracking task, oxytocin reduced interoceptive accuracy, but did not interact with alcohol consumption. On the discrimination task, we found an interaction between oxytocin administration and alcohol intake: Oxytocin, compared with placebo, increased interoceptive accuracy in heavy drinkers, but not in light social drinkers. Our study does not suggest a pure interoceptive impairment in alcohol users but instead potentially highlights reduced flexibility of internal and external attentional resource allocation. Importantly, this impairment seems to be mitigated by oxytocin. This attentional hypothesis needs to be explicitly tested in future research.
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影响因子：
3.7
作者：
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通讯作者：
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