Dynamic action of carotenoids in cardioprotection and maintenance of cardiac health.
Dynamic action of carotenoids in cardioprotection and maintenance of cardiac health.
复制标题
类胡萝卜素在心脏健康中的动态作用。
DOI：
10.3390/molecules17044755
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发表时间：
2012-04-23
期刊：
影响因子：
--
通讯作者：
Das DK
中科院分区：
文献类型：
--
作者：
Agarwal M;Parameswari RP;Vasanthi HR;Das DK
氧化应激被普遍认为与所有主要疾病的发病机制有关，包括心血管系统的疾病。氧化应激激活转录信使，如核因子-κB，明确地促进内皮功能障碍、动脉粥样硬化的发生和发展、缺血再灌注后的不可逆转损伤，甚至心律失常，如心房颤动。迅速积累的证据支持活性氧(ROS)和活性氮(RNS)作为细胞内信号分子的作用。尽管氧化应激与心血管疾病(CVD)之间存在这种联系，但目前还没有公认的治疗干预措施来满足这一重要的未得到满足的需求。根据流行病学、饮食和活体动物模型数据，通过ROS/RNS猝灭或自由基链断裂提供广泛的“上游”途径的抗氧化剂似乎是一种合适的治疗选择。短期饮食干预试验表明，富含水果和蔬菜的饮食可以改善冠状动脉危险因素，降低心血管死亡率。类胡萝卜素是如此丰富的植物来源的脂溶色素，具有抗氧化剂的功能。它们储存在肝脏或脂肪组织中，在运输过程中被合并到血浆脂蛋白颗粒中，是脂溶的。出于这些原因，类胡萝卜素可能是水果和蔬菜降低心血管疾病(CVD)等慢性疾病风险的一种合理机制。这篇综述文章概述了类胡萝卜素在维持心脏健康和心脏保护中的作用，这些作用是通过包括氧化还原信号在内的多种机制来实现的。
Oxidative stress has been considered universally and undeniably implicated in the pathogenesis of all major diseases, including those of the cardiovascular system. Oxidative stress activate transcriptional messengers, such as nuclear factor—κB, tangibly contributing to endothelial dysfunction, the initiation and progression of atherosclerosis, irreversible damage after ischemic reperfusion, and even arrhythmia, such as atrial fibrillation. Evidence is rapidly accumulating to support the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) as intracellular signaling molecules. Despite this connection between oxidative stress and cardiovascular disease (CVD), there are currently no recognized therapeutic interventions to address this important unmet need. Antioxidants that provide a broad, “upstream” approach via ROS/RNS quenching or free radical chain breaking seem an appropriate therapeutic option based on epidemiologic, dietary, and in vivo animal model data. Short-term dietary intervention trials suggest that diets rich in fruit and vegetable intake lead to improvements in coronary risk factors and reduce cardiovascular mortality. Carotenoids are such abundant, plant-derived, fat-soluble pigments that functions as antioxidants. They are stored in the liver or adipose tissue, and are lipid soluble by becoming incorporated into plasma lipoprotein particles during transport. For these reasons, carotenoids may represent one plausible mechanism by which fruits and vegetables reduce the risk of chronic diseases as cardiovascular disease (CVD). This review paper outlines the role of carotenoids in maintaining cardiac health and cardioprotection mediated by several mechanisms including redox signaling.
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影响因子：
7.1
作者：
DI MASCIO, P;MURPHY, ME;SIES, H
通讯作者：
SIES, H
DOI：
10.1016/1011-1344(91)80266-k
发表时间：
1991-10-01
影响因子：
5.4
作者：
CONN, PF;SCHALCH, W;TRUSCOTT, TG
通讯作者：
TRUSCOTT, TG
影响因子：
37.8
作者：
Gao, WD;Liu, YG;Marban, E
通讯作者：
Marban, E
影响因子：
1.9
作者：
Agarwal, S;Rao, AV
通讯作者：
Rao, AV
影响因子：
6.1
作者：
Gross, GJ;Lockwood, SF
通讯作者：
Lockwood, SF