Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.
Amplitude of low frequency fluctuation abnormalities in adolescents with online gaming addiction.
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网络游戏成瘾青少年低频波动异常幅度。
DOI：
10.1371/journal.pone.0078708
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Tian J
中科院分区：
文献类型：
--
作者：
Yuan K;Jin C;Cheng P;Yang X;Dong T;Bi Y;Xing L;von Deneen KM;Yu D;Liu J;Liang J;Cheng T;Qin W;Tian J
以往的大多数神经影像学研究表明，青少年网络游戏成瘾（OGA）的结构和任务相关的功能异常。然而，很少有功能磁共振成像（fMRI）的研究集中在局部强度的自发波动的血氧水平依赖（BOLD）在静息状态下，更少的研究探讨之间的关系异常静息状态的属性和受损的认知控制能力。本研究采用低频波动幅度（ALFF）方法探讨青少年OGA患者和健康对照者静息状态下自发脑活动的局部特征。18名青少年OGA和18名年龄，教育和性别匹配的健康志愿者参加了这项研究。与健康对照组相比，OGA青少年左侧内侧眶额皮质（OFC）、左侧楔前叶、左侧辅助运动区（SMA）、右侧海马旁回（PHG）和双侧中扣带回（MCC）的ALFF值显著增加。这些区域的异常在以前的成瘾研究中也被发现。更重要的是，我们发现左内侧眶额皮层和左楔前叶的ALFF值与青少年OGA的持续时间呈正相关。左内侧眶额皮层的ALFF值也与色词Stroop测验成绩相关。我们的研究结果表明，这些区域的异常自发神经元活动可能涉及OGA的潜在病理生理。
The majority of previous neuroimaging studies have demonstrated both structural and task-related functional abnormalities in adolescents with online gaming addiction (OGA). However, few functional magnetic resonance imaging (fMRI) studies focused on the regional intensity of spontaneous fluctuations in blood oxygen level-dependent (BOLD) during the resting state and fewer studies investigated the relationship between the abnormal resting-state properties and the impaired cognitive control ability. In the present study, we employed the amplitude of low frequency fluctuation (ALFF) method to explore the local features of spontaneous brain activity in adolescents with OGA and healthy controls during resting-state. Eighteen adolescents with OGA and 18 age-, education- and gender-matched healthy volunteers participated in this study. Compared with healthy controls, adolescents with OGA showed a significant increase in ALFF values in the left medial orbitofrontal cortex (OFC), the left precuneus, the left supplementary motor area (SMA), the right parahippocampal gyrus (PHG) and the bilateral middle cingulate cortex (MCC). The abnormalities of these regions were also detected in previous addiction studies. More importantly, we found that ALFF values of the left medial OFC and left precuneus were positively correlated with the duration of OGA in adolescents with OGA. The ALFF values of the left medial OFC were also correlated with the color-word Stroop test performance. Our results suggested that the abnormal spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology of OGA.
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影响因子：
3
作者：
Chao-Gan Y;Yu-Feng Z
通讯作者：
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DOI：
10.1089/109493101300210286
发表时间：
2001-06-01
期刊：
CYBERPSYCHOLOGY & BEHAVIOR
影响因子：
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作者：
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通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
6.1
作者：
Liu Jun;Gao Xue-ping;Li Ling-jiang
通讯作者：
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