Differential regional immune response in Chagas disease.
Differential regional immune response in Chagas disease.
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DOI：
10.1371/journal.pntd.0000417
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发表时间：
2009-07-07
影响因子：
3.8
通讯作者：
Savino W
中科院分区：
文献类型：
--
作者：
de Meis J;Morrot A;Farias-de-Oliveira DA;Villa-Verde DM;Savino W
感染后，淋巴细胞呈指数级扩增并分化为效应细胞以控制感染并协调免疫应答的多个效应臂。在这种扩增后不久，大多数抗原特异性淋巴细胞死亡，从而保持体内平衡，并形成一小部分记忆细胞，为随后的再感染提供长期免疫力。感染的程度和病原体清除率被认为决定了细胞扩张的幅度和稳态收缩到稳定数量的记忆细胞。T细胞反应的动力学和淋巴组织细胞数量的动力学之间的这种直接相关性是由在反应过程中被清除的病原体产生的急性感染中的恒定特征。然而，对能够建立持续感染的病原体的免疫反应的区域动态仍然知之甚少。在此，我们讨论了不同的中枢和外周淋巴器官急性感染锥虫克氏锥虫，南美锥虫病的病原体的淋巴细胞动力学的差异。当胸腺和肠系膜淋巴结经历严重萎缩伴大量淋巴细胞耗竭时，脾脏和皮下淋巴结由于T和B细胞活化/增殖而扩张。这些事件由细胞因子以及寄生虫衍生的部分调节。在这方面，确定局部淋巴细胞动力学继发于T。cruzi感染可能有助于设计新的免疫干预策略来控制这种感染的病理学。
Following infection, lymphocytes expand exponentially and differentiate into effector cells to control infection and coordinate the multiple effector arms of the immune response. Soon after this expansion, the majority of antigen-specific lymphocytes die, thus keeping homeostasis, and a small pool of memory cells develops, providing long-term immunity to subsequent reinfection. The extent of infection and rate of pathogen clearance are thought to determine both the magnitude of cell expansion and the homeostatic contraction to a stable number of memory cells. This straight correlation between the kinetics of T cell response and the dynamics of lymphoid tissue cell numbers is a constant feature in acute infections yielded by pathogens that are cleared during the course of response. However, the regional dynamics of the immune response mounted against pathogens that are able to establish a persistent infection remain poorly understood. Herein we discuss the differential lymphocyte dynamics in distinct central and peripheral lymphoid organs following acute infection by Trypanosoma cruzi, the causative agent of Chagas disease. While the thymus and mesenteric lymph nodes undergo a severe atrophy with massive lymphocyte depletion, the spleen and subcutaneous lymph nodes expand due to T and B cell activation/proliferation. These events are regulated by cytokines, as well as parasite-derived moieties. In this regard, identifying the molecular mechanisms underlying regional lymphocyte dynamics secondary to T. cruzi infection may hopefully contribute to the design of novel immune intervention strategies to control pathology in this infection.
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影响因子：
3.1
作者：
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通讯作者：
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