Flavonoid analyses and antimicrobial activity of various parts of Phaleria macrocarpa (Scheff.) Boerl fruit.
Flavonoid analyses and antimicrobial activity of various parts of Phaleria macrocarpa (Scheff.) Boerl fruit.
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DOI：
10.3390/ijms12063422
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发表时间：
2011
影响因子：
5.6
通讯作者：
Oskoueian E
中科院分区：
文献类型：
--
作者：
Hendra R;Ahmad S;Sukari A;Shukor MY;Oskoueian E
大果鬼针草Phaleria macrocarpa（Scheff.）Boerl（百里香科）通常被称为“上帝之冠”，“Mahkota Dewa”和“Pau”。它起源于印度尼西亚的巴布亚岛，生长在热带地区。经验表明，它对高血压、糖尿病、癌症和利尿患者有很好的治疗作用。它有着悠久的民族药理学使用的历史，和缺乏有关其生物活性的信息，导致我们调查可能的生物活性，通过黄酮类化合物的特性和对病原菌和真菌的抗微生物活性的不同部分。结果表明，山柰酚、杨梅素、柚皮苷和芦丁是果皮中的主要黄酮类化合物，而柚皮苷和槲皮素则存在于中果皮和种子中。在0.3mg/片浓度下，大果杨果实不同部位对病原菌的抑菌活性表现为中等抑菌能力，抑菌范围为0.93- 2.17cm。在0.3mg/孔的浓度下，仅在种子提取物中发现对黑曲霉（Aspergillus尼日尔）（1.87cm）的抗真菌活性。结果表明，大果杨果实中含有黄酮类化合物，可作为天然抗菌剂来源。
Phaleria macrocarpa (Scheff.) Boerl (Thymelaceae) is commonly known as ‘Crown of God’, ‘Mahkota Dewa’, and ‘Pau’. It originates from Papua Island, Indonesia and it grows in tropical areas. Empirically, it is potent in treating the hypertensive, diabetic, cancer and diuretic patients. It has a long history of ethnopharmacological usage, and the lack of information about its biological activities led us to investigate the possible biological activities by characterisation of flavonoids and antimicrobial activity of various part of P. macrocarpa against pathogenic bacteria and fungi. The results showed that kaempferol, myricetin, naringin, and rutin were the major flavonoids present in the pericarp while naringin and quercetin were found in the mesocarp and seed. Furthermore, the antibacterial activity of different parts of P. macrocarpa fruit showed a weak ability to moderate antibacterial activity against pathogenic tested bacteria (inhibition range: 0.93–2.17 cm) at concentration of 0.3 mg/disc. The anti fungi activity was only found in seed extract against Aspergillus niger (1.87 cm) at concentration of 0.3 mg/well. From the results obtained, P. macrocarpa fruit could be considered as a natural antimicrobial source due to the presence of flavonoid compounds.
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影响因子：
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