Does background postnatal methyl mercury exposure in toddlers affect cognition and behavior?
Does background postnatal methyl mercury exposure in toddlers affect cognition and behavior?
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DOI：
10.1016/j.neuro.2009.10.017
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发表时间：
2010-01
期刊：
影响因子：
3.4
通讯作者：
Rogan WJ
中科院分区：
文献类型：
--
作者：
Cao Y;Chen A;Jones RL;Radcliffe J;Caldwell KL;Dietrich KN;Rogan WJ
由于汞(Hg)对儿童发育中的中枢神经系统的毒理作用比成人更严重，因此人们越来越关注产前和儿童早期汞暴露。这项研究调查了参加铅(铅)暴露儿童临床试验(TLC)的780名儿童的出生后甲基汞(MeHg)暴露以及认知和行为，其中396名儿童被分配到琥珀酰组，384名儿童被分配到安慰剂组。汞暴露通过随机前1周和治疗开始后1周的血样分析来确定，此时琥珀酸对血铅(PBB)的影响最大。安慰剂组和琥珀酸组治疗前甲基汞浓度分别为0.5 4μg/L和0.5 2μg/L，治疗后分别为0.5 1μg/L和0.48μg/L。由于两组的基线特征是平衡的，由于琥珀酸对甲基汞浓度的影响很小，对认知或行为测试分数也没有影响，所以两组在甲基汞和神经发育的分析中结合在一起。在2岁、5岁和7岁时对儿童进行智商和神经行为表现测试。在分层、样条回归和广义线性模型数据分析中，我们发现血液中甲基汞与智商测试分数之间的微弱、不显著但一致的正相关。行为问题得分随着甲基汞浓度的增加而不变或略有下降。多变量模型中对PBB水平的额外调整不会改变甲基汞和智商得分的结论，但确实证实了并发PBB与TLC儿童的智商和行为密切相关。甲基汞对神经发育指数的影响在不同的PBB层级中没有显著差异。我们的结论是，在目前美国儿童出生后甲基汞暴露水平的背景下，对儿童智商和行为的不良影响是不可检测的。
Because the toxicological effects of mercury (Hg) are more serious in the developing central nervous system of children than adults, there are growing concerns about prenatal and early childhood Hg exposure. This study examined postnatal methylmercury (MeHg) exposure and cognition and behavior in 780 children enrolled in the Treatment of Lead (Pb) - exposed Children clinical trial (TLC) with 396 children allocated to the succimer and 384 to the placebo groups. Mercury exposure was determined from analyses of blood drawn 1 week before randomization and 1 week after treatment began when succimer had its maximal effect on blood Pb (PbB). The baseline MeHg concentrations were 0.54 μg/L and 0.52 μg/L and post-treatment concentrations were 0.51 μg/L and 0.48 μg/L for placebo and succimer groups respectively. Because the baseline characteristics in the two groups were balanced and because succimer had little effect on MeHg concentration and no effect on the cognitive or behavioral test scores, the groups were combined in the analysis of MeHg and neurodevelopment. The children's IQ and neurobehavioral performance were tested at age 2, 5 and 7 years. We saw weak, non-significant but consistently positive associations between blood MeHg and IQ test scores in stratified, spline regression and generalized linear model data analyses. The behavioral problem scores were constant or decreased slightly with increasing MeHg concentration. Additional adjustment for PbB levels in multivariable models did not alter the conclusion for MeHg and IQ scores, but did confirm that concurrent PbB was strongly associated with IQ and behavior in TLC children. The effects of MeHg on neurodevelopmental indices did not substantially differ by PbB strata. We conclude that at the present background postnatal MeHg exposure levels of US children, adverse effects on children's IQ and behavior are not detectable.
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