Structural comparison of metabolic networks in selected single cell organisms.
Structural comparison of metabolic networks in selected single cell organisms.
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DOI：
10.1186/1471-2105-6-8
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发表时间：
2005-01-14
影响因子：
3
通讯作者：
Qin ZS
中科院分区：
文献类型：
--
作者：
Zhu D;Qin ZS
人们对生物网络结构的研究产生了极大的兴趣。已经设想了一系列测量来评估这些网络的拓扑特性。在本研究中，我们利用这些测量结果比较了代表生命三个领域的11个单细胞生物的代谢网络结构，希望找出这些测量结果所反映的内在网络设计原理在生命三个领域的物种之间是否存在差异。本研究使用了三组拓扑特性：网络指数、度分布测量和主题轮廓测量。除了边际度分布之外，所有这些都是更高层次的拓扑性质。发现古菌物种的代谢网络在几乎所有测量的高级拓扑特性中都与酿酒酵母和六种细菌物种的代谢网络不同。我们的研究结果还表明古菌物种的代谢网络类似于指数随机网络。如果所研究的生物体的这些代谢网络特性可以扩展到各自领域的其他物种（这是可能的），那么古细菌的设计原理与细菌和真核生物的设计原理有根本的不同。此外，本研究揭示的古菌代谢网络的功能机制与细菌和真核生物的功能机制显着不同，值得进一步研究。
There has been tremendous interest in the study of biological network structure. An array of measurements has been conceived to assess the topological properties of these networks. In this study, we compared the metabolic network structures of eleven single cell organisms representing the three domains of life using these measurements, hoping to find out whether the intrinsic network design principle(s), reflected by these measurements, are different among species in the three domains of life. Three groups of topological properties were used in this study: network indices, degree distribution measures and motif profile measure. All of which are higher-level topological properties except for the marginal degree distribution. Metabolic networks in Archaeal species are found to be different from those in S. cerevisiae and the six Bacterial species in almost all measured higher-level topological properties. Our findings also indicate that the metabolic network in Archaeal species is similar to the exponential random network. If these metabolic network properties of the organisms studied can be extended to other species in their respective domains (which is likely), then the design principle(s) of Archaea are fundamentally different from those of Bacteria and Eukaryote. Furthermore, the functional mechanisms of Archaeal metabolic networks revealed in this study differentiate significantly from those of Bacterial and Eukaryotic organisms, which warrant further investigation.
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