African origin of the malaria parasite Plasmodium vivax.
African origin of the malaria parasite Plasmodium vivax.
复制标题
疟疾寄生虫疟原虫的非洲起源。
DOI：
10.1038/ncomms4346
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发表时间：
2014
影响因子：
16.6
通讯作者：
Sharp, Paul M.
中科院分区：
文献类型：
--
作者：
Liu, Weimin;Li, Yingying;Shaw, Katharina S.;Learn, Gerald H.;Plenderleith, Lindsey J.;Malenke, Jordan A.;Sundararaman, Sesh A.;Ramirez, Miguel A.;Crystal, Patricia A.;Smith, Andrew G.;Bibollet-Ruche, Frederic;Ayouba, Ahidjo;Locatelli, Sabrina;Esteban, Amandine;Mouacha, Fatima;Guichet, Emilande;Butel, Christelle;Ahuka-Mundeke, Steve;Inogwabini, Bila-Isia;Ndjango, Jean-Bosco N.;Speede, Sheri;Sanz, Crickette M.;Morgan, David B.;Gonder, Mary K.;Kranzusch, Philip J.;Walsh, Peter D.;Georgiev, Alexander V.;Muller, Martin N.;Piel, Alex K.;Stewart, Fiona A.;Wilson, Michael L.;Pusey, Anne E.;Cui, Liwang;Wang, Zenglei;Farnert, Anna;Sutherland, Colin J.;Nolder, Debbie;Hart, John A.;Hart, Terese B.;Bertolani, Paco;Gillis, Amethyst;LeBreton, Matthew;Tafon, Babila;Kiyang, John;Djoko, Cyrille F.;Schneider, Bradley S.;Wolfe, Nathan D.;Mpoudi-Ngole, Eitel;Delaporte, Eric;Carter, Richard;Culleton, Richard L.;Shaw, George M.;Rayner, Julian C.;Peeters, Martine;Hahn, Beatrice H.;Sharp, Paul M.
间日疟原虫是亚洲和拉丁美洲人类疟疾的主要原因，但在中非大部分地区不存在，因为其突变几乎固定在人类红细胞上，抑制其受体达菲抗原的表达。这种保护性等位基因的出现尚不清楚，因为间日疟原虫被认为起源于亚洲。在这里，我们使用非侵入性方法表明，整个非洲中部的野生黑猩猩和大猩猩都感染了与人类间日疟原虫密切相关的寄生虫。序列分析表明，猿寄生虫缺乏宿主特异性，并且比人类寄生虫更加多样化，人类寄生虫在猿寄生虫辐射内形成单系谱系。这些发现表明，人类间日疟原虫起源于非洲，很可能因达菲阴性突变而被选择。所有现存的人类间日疟原虫寄生虫都源自逃离非洲的单一祖先。
Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. vivax is believed to have originated in Asia. Here we show, using a non-invasive approach, that wild chimpanzees and gorillas throughout central Africa are endemically infected with parasites that are closely related to human P. vivax. Sequence analyses reveal that ape parasites lack host specificity and are much more diverse than human parasites, which form a monophyletic lineage within the ape parasite radiation. These findings indicate that human P. vivax is of African origin and likely selected for the Duffy-negative mutation. All extant human P. vivax parasites are derived from a single ancestor that escaped out of Africa.
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影响因子：
64.8
作者：
Keele, Brandon F.;Jones, James Holland;Terio, Karen A.;Estes, Jacob D.;Rudicell, Rebecca S.;Wilson, Michael L.;Li, Yingying;Learn, Gerald H.;Beasley, T. Mark;Schumacher-Stankey, Joann;Wroblewski, Emily;Mosser, Anna;Raphael, Jane;Kamenya, Shadrack;Lonsdorf, Elizabeth V.;Travis, Dominic A.;Mlengeya, Titus;Kinsel, Michael J.;Else, James G.;Silvestri, Guido;Goodall, Jane;Sharp, Paul M.;Shaw, George M.;Pusey, Anne E.;Hahn, Beatrice H.
通讯作者：
Hahn, Beatrice H.
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
DOI：
10.4269/ajtmh.1970.19.190
发表时间：
1970-01-01
影响因子：
3.3
作者：
CONTACOS, PG;COATNEY, GR;JETER, MH
通讯作者：
JETER, MH
影响因子：
9.8
作者：
Hamblin, MT;Di Rienzo, A
通讯作者：
Di Rienzo, A
影响因子：
56.9
作者：
Keele, Brandon F.;Van Heuverswyn, Fran;Hahn, Beatrice H.
通讯作者：
Hahn, Beatrice H.