COVID-19 vaccine platforms: Delivering on a promise?
COVID-19 vaccine platforms: Delivering on a promise?
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DOI：
10.1080/21645515.2021.1911204
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发表时间：
2021-09-02
影响因子：
4.8
通讯作者：
Atouf F
中科院分区：
文献类型：
--
作者：
Verdecia M;Kokai-Kun JF;Kibbey M;Acharya S;Venema J;Atouf F
新型SARS-CoV-2和COVID-19的出现使人们对预防这种疾病的疫苗的需求成为焦点。自200多年前向公众介绍疫苗以来，疫苗挽救了数百万人的生命。在世纪中期，随着技术的发展，扩大了制造新型疫苗的能力，疫苗接种的潜力达到了新的高度。从那时起，疫苗开发的技术不断进步。由此产生的平台为许多传染病提供了解决方案，包括那些已经伴随我们几十年的传染病以及那些刚刚出现的传染病。每个疫苗平台都代表着一种不同的技术，具有独特的优势和挑战，特别是在考虑制造时。因此，必须将每个平台理解为一个单独的产品和流程，并考虑其特定的质量因素。本文综述了开发SARS-CoV-2疫苗的相关平台，并讨论了每种平台的优点和缺点。
The emergence of the novel SARS-CoV-2 and COVID-19 has brought into sharp focus the need for a vaccine to prevent this disease. Vaccines have saved millions of lives since their introduction to the public over 200 years ago. The potential for vaccination reached new heights in the mid-20th century with the development of technologies that expanded the ability to create novel vaccines. Since then, there has been continued technological advancement in vaccine development. The resulting platforms provide the promise for solutions for many infectious diseases, including those that have been with us for decades as well as those just now emerging. Each vaccine platform represents a different technology with a unique set of advantages and challenges, especially when considering manufacturing. Therefore, it is essential to understand each platform as a separate product and process with its specific quality considerations. This review outlines the relevant platforms for developing a vaccine for SARS-CoV-2 and discusses the advantages and disadvantages of each.
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影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA
DOI：
10.1038/mtm.2016.30
发表时间：
2016
期刊：
Molecular therapy. Methods & clinical development
影响因子：
--
作者：
Afkhami S;Yao Y;Xing Z
通讯作者：
Xing Z
影响因子：
17.1
作者：
Bentebibel SE;Lopez S;Obermoser G;Schmitt N;Mueller C;Harrod C;Flano E;Mejias A;Albrecht RA;Blankenship D;Xu H;Pascual V;Banchereau J;Garcia-Sastre A;Palucka AK;Ramilo O;Ueno H
通讯作者：
Ueno H
影响因子：
3
作者：
Adhikari, Bishwa B.;Goodson, James L.;Meltzer, Martin I.
通讯作者：
Meltzer, Martin I.
影响因子：
5
作者：
Ahmad, Mudassar;Hirz, Melanie;Pichler, Harald;Schwab, Helmut
通讯作者：
Schwab, Helmut