Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study.
Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study.
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DOI：
10.2337/dc10-2116
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发表时间：
2011-08
期刊：
影响因子：
16.2
通讯作者：
Lind L
中科院分区：
文献类型：
--
作者：
Lee DH;Lind PM;Jacobs DR Jr;Salihovic S;van Bavel B;Lind L
持久性有机污染物（POP），主要在脂肪组织中积累的亲脂性化学物质，最近与2型糖尿病有关。然而，来自前瞻性研究的证据很少。本研究旨在评估老年人中2型糖尿病与选定POP的前瞻性关联。19种持久性有机污染物（14种多氯联苯[PCB]同系物，3种有机氯农药，1种溴化二苯醚和1种二恶英）在基线时收集的725名参与者的血浆中进行了测量，年龄70岁，乌普萨拉老年人血管系统的前瞻性调查（PIVUS）。在调整了已知的2型糖尿病风险因素（包括肥胖）后，根据多氯联苯浓度的五分位数，年龄75岁（n = 36）的2型糖尿病的比值比（OR）（95% CI）（与最低五分位数相比）分别为4.5、5.1、8.8（1.8-42.7）和7.5（1.4-38.8）（P趋势<0.01）。在有机氯农药中，反式-九甲草胺各浓度的调整OR值显示，Ptrend = 0.03。三种有机氯农药总量的五分位数校正OR（95%CI）分别为1.1、1.6、1.5和3.4（1.0-11.7）（P趋势= 0.03）。溴化二苯醚47和二恶英均与糖尿病发病率无显著相关性。当将多氯联苯的总和添加到糖尿病的传统风险因素中时，可显着改善重新分类。尽管事件病例数量很少，但这项研究发现，环境中暴露于某些持久性有机污染物大大增加了老年人群未来患2型糖尿病的风险。
Persistent organic pollutants (POPs), lipophilic chemicals that accumulate mainly in adipose tissue, have recently been linked to type 2 diabetes. However, evidence from prospective studies is sparse. This study was performed to evaluate prospective associations of type 2 diabetes with selected POPs among the elderly. Nineteen POPs (14 polychlorinated biphenyl [PCB] congeners, 3 organochlorine pesticides, 1 brominated diphenyl ether, and 1 dioxin) were measured in plasma collected at baseline in 725 participants, aged 70 years, of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). After adjusting for known type 2 diabetes risk factors, including obesity, odds ratios (ORs) (95% CIs) for type 2 diabetes at age 75 years (n = 36) according to the quintiles of a summary measure of concentrations of PCBs (vs. the lowest quintile) were 4.5, 5.1, 8.8 (1.8–42.7), and 7.5 (1.4–38.8) (Ptrend <0.01). Among organochlorine pesticides, adjusted ORs across concentrations of trans-nonachlor showed that Ptrend = 0.03. Adjusted ORs (95% CIs) across quintiles of the sum of three organochlorine pesticides were 1.1, 1.6, 1.5, and 3.4 (1.0–11.7) (Ptrend = 0.03). Neither brominated diphenyl ether 47 nor dioxin was significantly associated with incident diabetes. The sum of PCBs improved reclassification significantly when added to traditional risk factors for diabetes. Despite the small number of incident cases, this study found that environmental exposure to some POPs substantially increased risk of future type 2 diabetes in an elderly population.
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影响因子：
5.4
作者：
Longnecker, MP;Michalek, JE
通讯作者：
Michalek, JE
DOI：
10.1093/jnci/91.9.779
发表时间：
1999-05-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Steenland, K;Piacitelli, L;Chang, LI
通讯作者：
Chang, LI
影响因子：
8.2
作者：
Lee, D.-H.;Lee, I.-K.;Jacobs, D. R., Jr.
通讯作者：
Jacobs, D. R., Jr.
影响因子：
10.4
作者：
Ruzzin J;Petersen R;Meugnier E;Madsen L;Lock EJ;Lillefosse H;Ma T;Pesenti S;Sonne SB;Marstrand TT;Malde MK;Du ZY;Chavey C;Fajas L;Lundebye AK;Brand CL;Vidal H;Kristiansen K;Frøyland L
通讯作者：
Frøyland L
环境污染物和人类健康风险分析中的脂质调整。
影响因子：
10.4
作者：
Schisterman, EF;Whitcomb, BW;Louis, GMB;Louis, TA
通讯作者：
Louis, TA