Does Serum Uric Acid Status Influence the Association Between Left Atrium Diameter and Atrial Fibrillation in Hypertension Patients?
Does Serum Uric Acid Status Influence the Association Between Left Atrium Diameter and Atrial Fibrillation in Hypertension Patients?
复制标题
血清尿酸状态是否影响高血压患者左心房直径与心房颤动之间的关联？
DOI：
10.3389/fcvm.2020.594788
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发表时间：
2020
影响因子：
3.6
通讯作者：
Xia Y
中科院分区：
文献类型：
--
作者：
Hidru TH;Tang Y;Liu F;Hui S;Gao R;Li D;Yang X;Xia Y
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Objective: Both serum uric acid (SUA) levels and left atrium diameter (LAD) associate with AF. However, the influence of SUA status for the associated risk of AF related to LAD in hypertension patients is currently unknown. Methods: We retrospectively analyzed a hospital-based sample of 9,618 hypertension patients. Standard electrocardiograms were performed on all patients and were interpreted by expert electro-physiologists. Results: Overall 1,028 (10.69%) patients had AF out of 9,618 patients. In men >65 years of age, the prevalence of AF in the1st, 2nd, and 3rd tertiles of SUA among those grouped in the third tertile of LAD were 9, 12.3, and 21.7%, respectively. In the hyperuricemia group, the OR (95% CI) of AF for the highest tertile of LAD in men ≤ 65 years of age was 3.150 (1.756, 5.651; P < 0.001). Similarly, the hyperuricemic men in the 3rd LAD tertile had a higher likelihood of AF than those belonging to the 1st tertile. The ORs and (95% CIs) were 3.150 (1.756, 5.651; P < 0.001) and 5.522 (2.932, 10.400; P ≤ 0.001) for patients ≤ 65 and >65 years of age. An increase in SUA values was significantly associated with an increased likelihood of AF among women at the top tertiles of LAD, with the OR (95% CI) = 4.593 (1.857, 11.358; P = 0.001). Also, men> 65 years of age with large LAD, present at the third tertile of SUA, had a higher likelihood of AF, with the OR (95% CI) = 2.427 (1.039, 5.667; P < 0.05). Conclusion: SUA levels and LAD are associated with AF in patients with hypertension and the risk of AF associated with LAD increases among those with hyperuricemia.
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影响因子：
4.6
作者：
Huang G;Xu RH;Xu JB;Liu Y;Liu ZH;Xie X;Zhang TJ
通讯作者：
Zhang TJ
影响因子：
6.1
作者：
Nyrnes, Audhild;Toft, Ingrid;Lochen, Maja-Lisa
通讯作者：
Lochen, Maja-Lisa
影响因子：
1.2
作者：
Liu, Tong;Zhang, Xiaowei;Li, Guangping
通讯作者：
Li, Guangping
影响因子：
3.5
作者：
Kuwabara, Masanari;Niwa, Koichiro;Hisatome, Ichiro
通讯作者：
Hisatome, Ichiro
影响因子：
6.2
作者：
Lang, Roberto M.;Badano, Luigi P.;Voigt, Jens-Uwe
通讯作者：
Voigt, Jens-Uwe