Nonionic Block Copolypeptide Micelles Containing a Hydrophobic racemic-Leucine Core.
Nonionic Block Copolypeptide Micelles Containing a Hydrophobic racemic-Leucine Core.
复制标题
非离子块共聚糖胶质胶束，其中含有疏水性的乳石核心核心。
DOI：
10.1021/ma101251x
复制
发表时间：
2010-07
期刊：
影响因子：
5.5
通讯作者：
Deming TJ
中科院分区：
文献类型：
--
作者：
Hanson JA;Li Z;Deming TJ
嵌段共聚物胶束已广泛用作治疗药物和诊断分子的载体。在这里，我们报道了非离子嵌段共聚肽 KPx(rac-L)y 的合成，它具有“反向”杆螺旋结构，由亲水性杆状 α 螺旋片段连接到无序的外消旋疏水片段组成。研究了这些嵌段共聚肽在水中的自组装，并对它们的组成进行了优化，以确定样品 KP100(rac-L)10，该样品能够形成界限分明的胶束，该胶束对稀释、高温和各种介质都非常稳定。结合电子显微镜和动态光散射测量来确定胶束结构。通过封装抗癌药物喜树碱来评估这些胶束作为药物递送载体的潜力。发现含有胶束的药物是稳定的。
Block copolymer micelles have been used extensively as carriers for therapeutic drugs and diagnostic molecules. Here, we report the synthesis of nonionic, block copolypeptides, KPx(rac-L)y, which have a “reversed” rod-coil structure composed of a hydrophilic, rod-like, α-helical segment attached to a disordered, racemic hydrophobic segment. The self assembly of these block copolypeptides in water was studied, and their compositions were optimized to identify a sample, KP100(rac-L)10, which is able to form well defined micelles that are very stable against dilution, high temperatures, and various media. Micelle structure was determined using a combination of electron microscopy and dynamic light scattering measurements. The potential of these micelles as drug delivery carriers was evaluated by encapsulation of the anticancer drug camptothecin. The drug containing micelles were found to be stable.
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影响因子：
5.5
作者：
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通讯作者：
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