Longitudinal Change of Refractive Error in Retinopathy of Prematurity Treated With Intravitreal Bevacizumab or Laser Photocoagulation.
Longitudinal Change of Refractive Error in Retinopathy of Prematurity Treated With Intravitreal Bevacizumab or Laser Photocoagulation.
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DOI：
10.1016/j.ajo.2022.03.020
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发表时间：
2022-08
影响因子：
4.2
通讯作者：
Fulton, Anne B.
中科院分区：
文献类型：
--
作者：
Wiecek, Emily;Akula, James D.;Vanderveen, Deborah K.;Mantagos, Iason S.;Wu, Carolyn;Curran, Amber -Lee;De Bruyn, Hanna;Peterson, Bridget;Fulton, Anne B.
比较前早产儿与使用玻璃体内贝伐单抗 (IVB) 或激光治疗的早产儿视网膜病变 (ROP) 的近视和屈光不正进展情况。回顾性临床队列研究。我们确定了 2011 年至 2020 年接受 IVB 治疗的 ROP 早产儿，并将他们的纵向散瞳验光数据与同一时间段内接受激光治疗的 ROP 婴儿进行了比较。接受 IVB 治疗的婴儿子集还接受了额外的激光治疗。我们纳入了 789 次累积就诊（中位时间为 3.2 年）的散瞳验光结果。我们使用具有对数衰减函数的线性混合效应模型来评估治疗后屈光度如何随年龄变化。总的来说，该模型估计了屈光的显着趋势（P < 0.001）——从轻微远视到相对更严重的近视状态。然而，无论是否使用 IVB 治疗，激光治疗眼睛的进展明显更快（P <0.001）。激光点的数量导致近视进展增加约 0.16D/100 个激光点。 ROP 阶段和区域对近视进展有显着影响，更严重的疾病导致近视进展更快。随机效应（包括个体受试者变异以及左眼和右眼的嵌套变异）占未由年龄和治疗解释的剩余变异的 86.4%。激光治疗重度 ROP 会增加重度近视的趋势。在我们的样本中，IVB 并不影响近视进展，但确实大大减少了治疗 ROP 所需的后续激光量。考虑到 ROP 阶段和区域的差异后，激光的效果仍然存在。这项回顾性队列研究使用线性混合效应模型来评估接受玻璃体内贝伐单抗、激光或两者联合治疗的 ROP 儿童屈光不正的进展情况。该模型估计激光治疗眼睛的近视进展速度明显快于 IVB 治疗眼睛，并且 IVB 不影响近视进展。 ROP 阶段和区域对近视进展有显着影响，更严重的疾病导致近视进展更快。
To compare progression of myopia and refractive error in former preterms with retinopathy of prematurity (ROP) treated using intravitreal bevacizumab (IVB) or laser. Retrospective clinical cohort study. We identified premature infants with ROP treated with IVB from 2011-2020 and compared their longitudinal cycloplegic refraction data to that of ROP infants treated with laser during the same timeframe. A subset of infants treated with IVB also underwent additional treatment with laser. We included cycloplegic refractions from 789 cumulative visits over median 3.2 years. We used a linear mixed-effects model with a log decay function to evaluate how refraction changed with age following treatment. In aggregate, the model estimated a significant (P < 0.001) trend in refraction—from slight hyperopia to relatively more myopic states. However, progression in laser-treated eyes was significantly (P <0.001) more rapid, regardless of treatment with IVB. The number of laser spots resulted in increased myopic progression by ~0.16D/100 laser spots. Both ROP stage and zone had a significant effect on myopic progression, with more severe disease resulting in faster myopic progression. Random effects, including individual subject variation with nested variance for left and right eye, accounted for 86.4% of the remaining variance not explained by age and treatment. Laser treatment for severe ROP increases the trend to severe myopia. In our sample, IVB did not affect myopic progression but did substantially reduce the amount of consequent laser required to treat ROP. The effect of laser persists after accounting for differences in ROP stage and zone. This retrospective cohort study used a linear mixed-effects model to evaluate how refractive error progressed in children treated for ROP with intravitreal bevacizumab, laser, or both. The model estimated myopic progression in laser-treated eyes was significantly more rapid than in those treated with IVB, and IVB did not affect myopic progression. Both ROP stage and zone had a significant effect on myopic progression, with more severe disease resulting in faster myopic progression.
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影响因子：
1.6
作者：
Garcia-Valenzuela, E;Kaufman, LM
通讯作者：
Kaufman, LM
DOI：
10.1097/iae.0000000000001125
发表时间：
2017-01-01
影响因子：
3.3
作者：
Yoon, Je Moon;Shin, Dong Hoon;Park, Won Soon
通讯作者：
Park, Won Soon
影响因子：
4.4
作者：
Moskowitz A;Hansen RM;Fulton AB
通讯作者：
Fulton AB
影响因子：
1.6
作者：
Holmstrom, Gerd;Larsson, Eva
通讯作者：
Larsson, Eva
影响因子：
4.4
作者：
Munro, Robert J.;Fulton, Anne B.;Akula, James D.
通讯作者：
Akula, James D.