Non-classical steroid signalling through SF-1 responsive genes: a key mechanism in environmental endocrine disruption, cancer, and aging

普遍存在的人造化学品模仿天然激素，存在于塑料、化妆品和阻燃剂中，造成内分泌干扰，已知会导致模式生物和野生动物的发育缺陷，对人类健康也有很大风险。这种风险随着人口密度的增加和对水循环的依赖而增加。目前评估这些物质的测试使用了过于简单的激素作用模式，严重低估了内分泌干扰的风险。这一提议将产生关于这些物质如何在体内或野生动物中起作用的新知识，并为更敏感的环境监测新方法奠定基础。

Endocrine disruption by pervasive manmade chemicals, which mimic natural hormones, and are found in plastics, cosmetics, and fire retardants, is known to cause developmental defects in model organisms and wildlife, with substantial risk also to human health. This risk increases with increasing population density and dependence on water recycling. Current tests to assess such substances use oversimplified modes of hormone action and grossly underestimate the risk of endocrine disruption. This proposal will yield new knowledge about how such substances act in the body, or on wildlife, and form the basis for new more sensitive methods of environmental monitoring.