Understanding the dynamics of T cell responses to chronic infection

慢性感染对澳大利亚和全球人口的健康、社会和经济影响是巨大的。开发针对慢性感染的疫苗的一个主要障碍是，我们对持续感染的免疫反应了解很少。我们的目标是利用生物信息学和数学模型来了解对持久性病毒的免疫反应，以便我们能够改善对慢性病毒感染的长期免疫控制，例如人类免疫缺陷病毒(HIV)。该项目将加强澳大利亚在免疫学跨学科方法领域的研究，这对解释使用先进实验技术获得的快速增长的数据量正变得至关重要。

The health, social, and economic impact of chronic infections on the Australian and global populations is enormous. A major obstacle to the development of vaccines against chronic infections is that we have a poor understanding of immune responses to persistent infections. We aim to use bioinformatics and mathematical modelling to understand immune responses to persistent viruses so that we can improve the long-term immune control of chronic viral infections such as the human immunodeficiency virus (HIV). This project will strengthen Australian research in the area of interdisciplinary approaches to immunology, which is becoming crucial to interpreting the rapidly increasing volume of data obtained using advanced experimental techniques.